Among children with asthma or rhinitis at the age of eight, higher blood levels of arachidonic
acid were associated with a higher probability of being symptom-free at age 16 years.
With initial innovation support from Karolinska Institutet Innovations AB, Gesynta Pharma AB leverages expertise in arachidonic
acid research to explore proprietary indications for mPGES-1 inhibitors.
One of the major pathways that take role in inflammation is arachidonic
acid (AA) metabolism.
2] is the most upstream enzyme in the arachidonic
acid cascade and releases arachidonic
acid from the plasma membrane.
acid has been reported to kill juvenile and adult schistosomes in vitro and to reduce worm burdens by 50% to 78% in mice and hamsters infected with S.
Samples from all 40 healthy donors were used for assessment of arachidonic
acid- and ADP-induced platelet function.
acid, one of PUFA acids, is a major substrate for the 12/15-LOX.
What to do: It's too early to know if DHA prevents knee cartilage loss or if arachidonic
acid causes knee inflammation.
Non-vegetarian diets are often high in arachidonic
Examples of n-6 PUFA are arachidonic
acid and n-3 PUFA are eicosapentaenoic acid.
They also noted that patients with higher blood levels of arachidonic
acid, an omega-6 fat found in red meat and poultry as well as fish and eggs, had more synovitis.
Omega-3 fatty acids inhibit an enzyme called cyclooxygenase and reduce the synthesis of arachidonic
acid, both of which are associated with inflammation in the body.