arginase

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arginase

[′ar·jə‚nās]
(biochemistry)
An enzyme that catalyzes the splitting of urea from the amino acid arginine.
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(NASDAQ: AGLE), a clinical-stage biotechnology company that engineers next-generation human enzymes to provide solutions for diseases with unmet medical need, today announced it will present new data on all 14 patients who have been administered 20 doses of pegzilarginase for Arginase 1 Deficiency (ARG1-D) from the completed Phase 1/2 clinical trial and the ongoing Phase 2 open-label extension study in a poster at the 2019 Symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM) in Rotterdam, the Netherlands, on Wednesday, September 4.
[CD11b.sup.+][Ly6C.sup.+] monocytes/macrophages were assessed for expression of M1 activation markers chemokine (C-X-C motif) ligand 9 (Cxcl9) and nitric oxide synthase 2 (Nos2) and M2 activation markers transglutaminase 2 (Tgm2) and arginase 1 (Arg1).
Besides, IL-4 and/or IL-13 activate STAT6 and increase the expression of STAT6-responsive genes such as arginase 1 and 15-lipoxygenase [6].
Placides et al., "Sustained arginase 1 expression modulates pathological tau deposits in a mouse model of tauopathy," Journal of Neuroscience, vol.
Given that arginase 1 reactivity was not observed in Iba1-positive cells of either genotype, this suggests that activated microglia temporarily appeared during development but did not show the typical arginase 1-positive M2 phenotype.
To further assess their differentiation we measured the expression of Elane (neutrophil elastase), Arg1 (arginase 1), and Hp (haptoglobin), all genes expressed in various differentiation steps in granulocytes [34-36].
'We made tremendous progress this quarter with pegzilarginase, our lead product candidate for the treatment of Arginase 1 Deficiency (ARG1-D),' said Anthony G.
Aeglea Bio Therapeutics said the FDA granted Breakthrough Therapy Designation to its lead investigational therapy pegzilarginase, for the treatment of Arginase 1 Deficiency, a rare progressive disease presenting in early childhood that results in severe complications and early mortality.
In alternatively activated macrophages, arginine is metabolized by the enzyme arginase 1 (Arg1) (Figure 2(b)).
Real-time PCR amplification was performed using Power SYBR qRT-PCR kits (Applied Biosystems, Foster City, CA) on a QuantStudio 5 analyzer (Applied Biosystems) for the following primers: heme oxygenase 1 (HO-1), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX1), superoxide dismutase 2 (SOD2), thioredoxin 1 (TRX1), platelet-derived growth factor subunit b (PDGFb), transforming growth factor beta 1 (TGF[beta]1), matrix metallopeptidase 9 (MMP9), arginase 1 (ARG1), lymphocyte antigen 6 complex (Ly6c), CD68, neutrophil elastase (ELANE), and inducible nitric oxide synthase (iNOS).
In addition, similar elevation of transferrin (TF), peroxiredoxin 1 (PRDX1) and 3 (PRDX3), and progesterone receptor membrane component 1 (PGRMC1) and downregulation of urea cycle enzymes such as arginase 1 (ARG1), carbamoyl-phosphate synthase 1 (CPS1), argininosuccinate lyase (ASL), ornithine carbamoyltransferase (OTC), and argininosuccinate synthase 1 (ASS1) in the surrounding liver tissue of both the [Ogg1.sup.-/-] and [Ogg1.sup.+/+] PB groups were found.