aristolochic acid


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aristolochic acid

[ə¦ris·tə¦läk·ik ′as·əd]
(organic chemistry)
C17H11NO7 Crystals in the form of shiny brown leaflets that decompose at 281-286°C; soluble in alcohol, chloroform, acetone, ether, acetic acid, and aniline; used as an aromatic bitter. Also known as aristolochine.
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Second, the lack of some clinicopathological parameters of the study cohort such as accurate information on aristolochic acid medication history, surgical margin status, and lymphovascular invasion status which may reduce the strength of this study.
They used several search engines to include all publications that are about or refer to aristolochic acid and Chinese herbal nephropathy and identified 42 different case studies and one trial relating to the management of the disease.
It is hoped the work will identify exactly how aristolochic acid causes cells to become cancerous.
For example, she said, aristolochic acid is not produced in the United States and the federal government has an import ban on it, so if the law were being enforced it would not be available for sale here.
Dirty Dozen: 12 Supplements to Avoid Name(s) Dangers Regulatory Actions DEFINITELY HAZARDOUS: Documented organ failure or known carcinogenic properties Aristolochic acid Potent human carcinogen; FDA warning to (Aristolochia, kidney failure, sometimes consumers and industry birthwort, requiring transplant; deaths and import alert in snakeroot, reported.
All three have been used as weight-loss aids, while aristolochic acid has also been used to alleviate gastrointestinal and other health problems.
They will first develop testing methods for supplements containing ephedrine-type alkaloids and aristolochic acid.
On May 31, 2000, the Food and Drug Administration issued a letter to health care professionals concerning the nephrotoxicity and carcinogenicity of botanical products containing aristolochic acid.
A mixture of Chinese herbs, including aristolochic acid, a nephrotoxic substance, has been used primarily by women for weight loss resulting in a unique type of chronic interstitial fibrosis of the kidney and tubular atrophy.
aristolochic acid and its salts, as well as Aristolochia spp and their preparations (substances that act as powerful carcinogens).
Aristolochic acid nephropathy resulting from its use as an additive in weight-loss drugs was first reported in Belgium.
The plants of the genera Aristolochia and Asarum became the interesting topic for the phytochemical and pharmaceutical researchers since the discovery of aristolochic acid derivatives.