artificial chromosome


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Related to artificial chromosome: Bacterial artificial chromosome

artificial chromosome

[‚ärd·ə¦fish·əl ′krō·mə‚sōm]
(genetics)
A functional chromosome constructed by genetic engineering, having a centromere (and a telomere at each end, if linear rather than circular) and thus transmissable in cell division after introduction into a cell.
References in periodicals archive ?
The global multiplexed molecular diagnostics market segmentation is based on technology (low density multiplexed assays, microplate assays, quantitative PCR, medium density multiplexed assays, antibody arrays, bead-based arrays, mass spectrometry, reverse arrays, high density multiplexed assays, bacterial artificial chromosome arrays, protein arrays, very high density multiplexed assays, oligonucleotide arrays, phage display, next generation sequencing assays), and applications (allergies, autoimmune diseases, cardiac disorders, infectious disease diagnosis, oncology).
Construction and preliminary characterization of a river buffalo bacterial artificial chromosome library.
Stem cell-mediated transfer of a human artificial chromosome ameliorates muscular dystrophy.
Artificial chromosomes is important for the synthetic life-forms that scientists expects to design for a range of applications, including industrial manufacture of new types of medicines and drugs for human and animal medicine, capability to generate new types of microbes with genetic codes that could generate cheaper ways to use crude oil as automotive fuel or create improved medicines without having harmful side effects.
Natalay Kouprina of the US National Cancer Institute in Bethesda, Maryland, who is a part of the team that successfully created genetically engineered mice with an extra human artificial chromosome in their cells, told the Independent that it is the first time such an advanced form of a synthetic human chromosome built 'from scratch' has been shown to work in an animal model.
But when they tried to insert it into another bacterium from which the DNA had been removed, the artificial chromosome didn't work.
In 2008, he showed that he could make an artificial chromosome with " watermark" DNA sequences that would distinguish synthetic genome from the natural one.
Additionally, we have successfully localized bindin genes (that produce species-specific vitelline membrane-binding protein) by using fluorescent in situ hybridization (FISH) and three fluorescently labeled bacterial artificial chromosome (BAC-FISH) clones (brachyury, foxa, and foxb) from the Caltech BAC library on chromosomes from both species of strongylocentrotid sea urchins.
In addition, Hehir-Kwa et al (11) assessed 4 genome-wide copy number profiling methods for their ability to detect submicroscopic single-copy number variations, and they determined that commercially available aCGH and SNP microarray platforms performed better than an in-house tiling resolution bacterial artificial chromosome array of 32 447 overlapping bacterial artificial chromosome clones.
Which is why Synthetic Genomics in Rockville, MD, has built the first fully artificial chromosome, a strand of DNA many times longer than anything made by others and laden with all the genetic components a microbe needs to get by.
ABSTRACT : As an initial step toward a better understanding of the genome structure of Korean cattle (Hanwoo breed) and initiation of the framework for genomic research in this bovine, the bacterial artificial chromosome (BAC) end sequencing of 21,024 clones was recently completed.

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