(2016) Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the
aspartic protease DDI-1.
Cold-adapted digestive
aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization.
The active site lies between the identical subunits and has the characteristic Asp-Thr-Gly (Asp25, Thr26, and Gly27) sequence common to
aspartic proteases. The two-subunit chains assemble to form a long tunnel covered by two flexible protein "flaps" which move a distance of up to 7 A when the enzyme becomes associated with a substrate [10].
Mechanism of Action of
Aspartic Protease.
Aspartic proteases (EC 3.4.23) are peptidases that exhibit various activities and specificities.
glabrata to produce proteases (
aspartic protease and caseinase), phospholipase, esterase, phytase, hemolysin, and catalase were evaluated.
Human immuno-deficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric
aspartic protease. Proc Natl Acad Sci USA 1989;86(6):1841-1845.
A study by Baeza et al has identified an
aspartic protease, a protein of ~33 kDa to render X.
Napsin A, a member of the
aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.
Designing a drug that could selectively inhibit BACE1 could avoid the unwanted side-effects of also inhibiting other
aspartic protease family members including BACE2.
A new class of inhibitors for the malarial
aspartic protease plasmepsin II based on a central 11-azatricyclo[6.2.1.0 (2), (7)]undeca-2,4,6-triene scaffold.
Antimalarial synergy of cysteine and
aspartic protease inhibitors.
The
aspartic protease pepsin (up to 62.5 U [mL.sup.-1]) had no effect on the antimicrobial activity of either tachyplesin or pleurocidin against V.