asymmetric synthesis

(redirected from Asymmetric catalysis)

asymmetric synthesis

[¦ā·sə¦me·trik ′sin·thə·səs]
(organic chemistry)
Chemical synthesis of a pure enantiomer, or of an enantiomorphic mixture in which one enantiomer predominates, without the use of resolution.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Chemists explain the theory, practice, and results of combining multiple distinct catalysts--at least one of them chiral--as a promising strategy to tackle challenges in achieving ideal asymmetric catalysis. The effects of such a multi-catalyst system can be classified into three types, they say: asymmetric cooperative catalysis (the simultaneous activation of distinct reaction partners), asymmetric double activation catalysis (double activation of one substrate), and asymmetric assisted catalysis (the generation of an enhanced catalytic species).
Summary: Development in the field of asymmetric catalysis is driven by the importance of stereochemically pure compounds in the field of pharmaceutical industry, agrochemicals and flavors.
Yamamoto, in Comprehensive Asymmetric Catalysis II, Springer, Berlin, Germany, 1999.
Cramer heads the laboratory of asymmetric catalysis and synthesis at the Ecole Polytechnique Federale (EPF) in Lausanne, Switzerland.
Among the topics are enantioselective annulations with chiral N-mesityl N-heterocyclic carbenes, the construction of anti-Me-OH vicinal relationships in polyketides, asymmetric catalysis in the total synthesis of lipids and polyketides, hetercycle construction via asymmetric rhodium-catalyzed cylcoadditions, and dynamic kinetic asymmetric transformations involving carbon-carbon bond cleavage.
Asymmetric catalysis therefore can offer a new direction to develop a new class of drugs and biomaterials.
Asymmetric catalysis using nanoparticle-based catalysts is quite rare, and could have its advantages.
Despite the fact that our resources were limited at the time, we were able to find spare parts and assemble a number of chromatography instruments to further our research on asymmetric catalysis. I noticed the chromatography columns were sensitive to temperature and solvents.
In this work, they present 13 review articles describing various aspects of this emerging field, including asymmetric synthesis of chiral sulfoxides, asymmetric synthesis of optically active sulfinic acid esters, asymmetric transformations mediated by sulfinyl groups, synthesis and applications of chiral dithiocetal derivatives, synthesis and use of chiral sulfur ylides, synthesis and use of chiral sulfoximines, synthesis and use of chiral sulfinamides, asymmetric catalysis using sulfoxides as ligands, sulfones in asymmetric catalysis, and computational studies on asymmetric reactions with sulfur reagents.
These valuable synthetic targets can be employed as efficient chiral [C.sub.2] auxiliaries for asymmetric synthesis or as ligands in asymmetric catalysis [2].