This work presents a new method for the asymmetric synthesis
of [gamma]-halo-[delta]-lactones 3, 5, 7 substrates for the synthesis of 6,6-dimethyl-4-isopropyl-3-oxabicydo [3.1.0] hexan-2-one as a source of enantiomerically pure cischrysanthemic acid.
The aspartato complexes were synthesized using asymmetric synthesis
via chiral pool syntheses while ion exchange chromatography was used in separating some of the compounds into their geometric isomers.
Despite major advances in organic synthesis predominantly over the past hundred years or so, asymmetric synthesis
of chiral organic compounds including the great majority of bioactive compounds, such as amino acids and their oligomers and polymers, i.e., peptides, has remained as one of the 'last bastions" to be conquered.
Specific topics include the redox isomerization of propargyl alcohols to enones, alkyne metathesis in organic synthesis, the catalytic enantioselective addition of terminal alkynes to carbonyls, the catalytic dimerization of alkynes, and the alkyne zipper reaction in asymmetric synthesis
. ([umlaut] Ringgold, Inc., Portland, OR)
Great progress has been made in the reaction and first reported in 1972 the reaction of acetaldehyde with ethyl acrylate and acetonitrile in the presence of catalytic amount of DABCO (1,4-diazabicyclo[2.2.2]octane) has been reported and named as Baylis-Hillman reaction and even a catalytic asymmetric synthesis
has been obtained from this reaction.
Yang et al., "Asymmetric synthesis
of [alpha] aminophosphonates using the inexpensive chiral catalyst 1,1'-binaphthol phosphate," Molecules, vol.
After a general introduction and glossary, they cover practical aspects of asymmetric synthesis
; enolate azaenolate, and organolithium alkylations; 1,2-additions and 1,4-additions to C=X bonds; aldol and Micheal additions of allyls, enolates, and enolate equivalents; cycloadditions and rearrangements; reductions and hydroborations, and oxidations.
Papadopoulos, "Green asymmetric synthesis
: b-amino alcohol-catalyzed direct asymmetric aldol reactions in aqueous micelles," Chirality, vol.
Synthesis of (2S)-(methanesulfonyloxy) Propanoyl Chloride, a Key Intermediate in the Asymmetric Synthesis
Boehringer Ingelheim (Canada) Research Excellence Award, sponsored by Boehringer Ingelheim (Canada) Ltd., for his research in asymmetric synthesis
, development of new synthetic methods and total synthesis of complex natural products.
The first is on asymmetric synthesis
of heterocycles containing only one heteroatom and is organized into chapters according to the size of the ring: azirdine, azetideine, pyrrolidine, piperidine, azepine and larger rings.