The ATP synthesis
involves a series of electron transport reactions in the inner mitochondrial membrane, where oxygen is an essential component to facilitate the oxidation of substrates that ultimately allows ATP production (Mitchell 1966, Boyer 1997).
1][epsilon] would be more flexible to cope with effects of the rotation driven by the proton motive force (pmf) during the ATP synthesis
than the structure of T[F.
Mitochondrial complex 1-driven ATP synthesis
assays (mtCIDAS) of vehicle- and CPC-treated LHON mutation (11,778) carrying osteosarcoma cybrid cells were performed as previously described with slight modification (Datta et al.
Melatonin addition in semen extender is reported to increase the ATP synthesis
that favors sperm quality parameters i.
Activity-driven local ATP synthesis
is required for synaptic function.
Our results point to NUDIX5 as key player in nuclear ATP synthesis
for chromatin remodeling.
Furthermore, we discovered that the Ndufc2 silencing in vascular cells led to a significant impairment of complex I assembly, to a reduction of mitochondrial membrane potential and of ATP synthesis
, with consequent marked accumulation of ROS, increased inflammation, increased cell necrosis, and reduced cell viability .
This process directly restores electron flow from complex III to cytochrome c and as a consequence, supports the mitochondrial proton gradient and ATP synthesis
by circumventing complex I-dependent electron transport [45,46].
Its toxicity is attributed to the presence of a hepatotoxic terpenoid known as atractyloside, a powerful inhibitor of cellular respiration and ATP synthesis
(phosphorylation) is dependent on electron transport.
The membrane sodium potassium ATPase mediated ATP synthesis
can serve as a source for cellular energetics.
phosphate groups to be used during ATP synthesis
as energy for the cell.