The cases of atypical ductal hyperplasia
associated with cancer reached a peak of 4.3 per 10,000 mammograms in 2003, but decreased to 3.3 in 2005.
In contrast, patients who were premenopausal when they had a breast biopsy showing atypical ductal hyperplasia
had a 2.59-fold increased risk of subsequent breast cancer, whereas those who were postmenopausal at the time of their benign biopsy had a 4.04-fold increased breast cancer risk, Dr.
Estrogen receptor and cytokeratin 5 are reliable markers to separate usual ductal hyperplasia from atypical ductal hyperplasia
and low-grade ductal carcinoma in situ.
Atypical ductal hyperplasia
at margin of breast biopsy--is re-excision indicated?
That worked out to an adjusted odds ratio for developing breast cancer of 2.76 for women with atypical ductal hyperplasia
, 5.24 for those with atypical lobular hyperplasia, and 8.12 for women with both histologic abnormalities, she continued.
(19) Specifically, 25 years after a diagnosis of atypical hyperplasia (atypical ductal hyperplasia
and ALH) on biopsy, breast cancer (in situ or invasive) developed in 29% of women.
Can mammographic findings help discriminate between atypical ductal hyperplasia
and ductal carcinoma in situ after needle core biopsy?
Additional objectives included determining the incidence of significant pathologic findings (SPF), defined as occult carcinoma and atypical hyperplasia (including atypical ductal hyperplasia
[ADH] and atypical lobular hyperplasia [ALH]), in RMP specimens.
Fibroadenoma is commonest seen in 27 cases (43.54%), benign breast disease in 15 cases (24.19%) and atypical ductal hyperplasia
in 04 cases (6.45%), breast abscess in 04 cases (6.45%), galactocele in 04 cases (6.45%), mastitis in 03 cases(4.83%), fibrocystic disease in 02 cases(3.22%), intraductal papilloma in one case(1.61%), phylloides in one case (1.61%).
Biopsies that showed atypical ductal hyperplasia
, atypical lobular hyperplasia, lobular carcinoma in situ, or flat epithelial atypia were grouped as atypical epithelial lesions.
(5,6) Common atypical pathologic findings in complex cystic breast masses include atypical ductal hyperplasia
and atypical papilloma.
Usual ductal hyperplasia (UDH) and atypical ductal hyperplasia
(ADH)/low-grade ductal carcinoma in situ (LG-DCIS) are biologically distinct, intraductal, epithelial proliferations with different clinical implications.