Evans syndrome is an uncommon condition characterised by Immune thrombocytopenia (ITP) and Autoimmune haemolytic anaemia
(AIHA) that can coexist or one follows the other, and it is diagnosed with a positive Direct antiglobulin test (DAT).
Benefits of rituximab as a second-line treatment for autoimmune haemolytic anaemia
in children: a prospective French cohort study.
Exclusion criteria: Patients were excluded from the study for the following reasons: Gestation, lactation, iron deficiency anaemia, rheumatoid collagen tissue diseases, celiac disease, Type-1 diabetes, pernicious anaemia, stage 3 and further chronic kidney disease, chronic hepatitis, primary biliary cirrhosis, portal hypertension, idiopathic thrombocytopenic purpura, idiopathic hypoparathyroidism, Addison disease, lymphocytic hypophysitis, colitis ulcerosa, Crohn's disease, Behcet's disease, sarcoidosis, bronchial asthma, autoimmune haemolytic anaemia
These include autoimmune haemolytic anaemia
(AIHA) and antibody mediated rejection (AMR) following organ transplantation.
In one report, there was a 4.3% absolute risk of autoimmune disorders in MM patients treated with lenalidomide especially if they had prior autologous transplant  Though autoimmune haemolytic anaemia
, idiopathic thrombocytopenic purpura, Evans syndrome, autoimmune thyroiditis, optic neuritis, cutaneous vasculitis, and polymyositis have been reported, to the best of our knowledge, we have not seen any cases of pernicious anaemia with lenalidomide .
of Cases % Hereditary Haemolytic Anaemia Thalassemia Major 12 23.07% Thalassemia Minor 1 1.97% Sickle Cell Anaemia 11 21.15% Sickle Cell Trait 4 7.69% Sickle Thalassemia 4 7.69% Hereditary Persistence of Foetal Haemoglobin 1 1.92% Acquired Haemolytic Anaemia Malaria 17 32.69% Autoimmune Haemolytic Anaemia
2 3.84% Age at First Presentation with Thalassemia Major Age in Months No.
Peters et al., "Autoimmune haemolytic anaemia
complicating haematopoietic cell transplantation in paediatric patients: high incidence and significant mortality in unrelated donor transplants for non-malignant diseases," British Journal of Haematology, vol.
Identification of autoantigens in canine autoimmune haemolytic anaemia
. Clin Exp Immunol.
Orchard et al., "Fludarabine-related autoimmune haemolytic anaemia
in patients with chronic lymphocytic leukaemia," British Journal of Haematology, vol.
Autoimmune haemolytic anaemia
is more common in HIV-infected patients than in HIV-negative patients.
(4.) O'Brien TA, Eastlund T, Peters Ch, Neglia JP, Defor T, Ramsay NK, Scott Baker K: Autoimmune haemolytic anaemia
complicating haematopoietic cell transplantation in paediatric patients: High incidente and significant mortality in unrelated donor transplants for non-malignant diseases.
Response to intravenous immunoglobulin G in an infant with immunoglobulin A-associated autoimmune haemolytic anaemia
. Vox Sang 2004;86(2):151-3.