Hershko, Avram

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Hershko, Avram,

1937–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1965, Ph.D. 1969. Hershko has been a professor at the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology), Haifa, since 1972. In 2004 he received the Nobel Prize in Chemistry with Aaron CiechanoverCiechanover, Aaron,
1947–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1974; D.Sc. Technion (Israel Institute of Technology), Haifa, 1982. He has been on the faculty at the Technion since 1986.
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 and Irwin RoseRose, Irwin,
1926–2015, American biochemist, b. Brooklyn, N.Y., Ph.D. Univ. of Chicago, 1952. Rose was on the faculty of Yale Medical School from 1954 to 1963 and a senior member of the Fox Chase Cancer Center in Philadelphia from 1963 until 1995.
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 for discovering the mechanism underlying protein degradation. Their work resulted in a molecular-level understanding of how cells control such processes as DNA repair, cell division, and immune functions by breaking down selected proteins using a regulatory tag called ubiquitin. This knowledge has helped in the fight against cystic fibrosis, cervical cancer, and other diseases that occur when the degradation process is flawed.
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References in periodicals archive ?
2004 Aaron Ciechanover, Avram Hershko and Irwin Rose "for the discovery of ubiquitin-mediated protein degradation"
BSF-sponsored U.S.-Israeli collaboration reached the pinnacle of scientific achievement in 2004, when the Nobel Prize for Chemistry was awarded to Professors Avram Hershko and Aaron Ciechanover of the Technion, and Professor Irwin Rose of the University of California, Irvine, for their joint discovery of the ubiquitin system of protein degradation, which regulates the breakdown of proteins governing almost all major functions of the cell.
Contudo, a sua relacao com a proteolise so viria a ser publicada no trabalho do professor/pesquisador Avram Hershko, na decada de 1980, que culminaria no premio Nobel de quimica em 2004.
"I traveled to Israel when Menachem Begin was prime minister and visited the Technion, where your two Nobel Prize-winning scientists are conducting their research." (Technion Professors Avram Hershko and Aaron Ciechanover, whose research has been funded by ICRF for 22 years, received the 2004 Nobel Prize in chemistry for discovering a process that lets cells destroy unwanted proteins--the ubiquitin system.)
The Royal Swedish Academy of Sciences chose Irwin Rose, 78, of the University of California, Irvine, and Avram Hershko, 67, and Aaron Ciechanover, 57, both of the Israel Institute of Technology, in Halla, Israel, "for the discovery of ubiquitin-mediated protein degradation." These scientists discovered the method by which cells tag defective proteins (or proteins that have outlived their usefulness) and direct them to the cellular machinery that grinds them into reuseable parts.
Aaron Ciechanever, 57, and Avram Hershko, 67, of the Technion-Israel Institute of Technology in Haifa and Irwin Rose, 78, of the University of California, Irvine will share the roughly $1.4 million prize.
Aaron Ciechanover and Avram Hershko of the Technion-Israel Institute of Technology in Haifa and Irwin Rose of the University of California, Irvine will share the prize, which was announced at press time.