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Related to Azelastine hydrochloride: Fluticasone, Fluticasone propionate


(ăn'tĭhĭs`təmēn), any one of a group of compounds having various chemical structures and characterized by the ability to antagonize the effects of histaminehistamine
, organic compound derived in the body from the amino acid histidine by the removal of a carboxyl group (COOH). Although found in many plant and animal tissues, histamine is specifically important in human physiology because it is one of the chemicals released from
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. Their principal use in medicine is in the control of allergies such as hay fever and hives. Some antihistamines are also useful as sedatives and for the prevention of motion sickness; others, such as fexofenadine (Allegra) and loratadine (Claritin) are nonsedating.


A type of drug that inhibits the combination of histamine with histamine receptors. These drugs are termed either H-1 or H-2 receptor antagonists depending on which type of histamine receptor is involved. H-1 receptor antagonists are used largely for treating allergies, and H-2 receptor antagonists are used to treat peptic ulcer disease and related conditions. See Histamine

The primary therapeutic use of H-1 receptor antagonists is to antagonize the effects of histamine released from cells by antigen-antibody reactions; they can thus inhibit histamine-induced effects, such as bronchoconstriction, skin reactions, for example, wheals and itching, and nasal inflammation. These drugs, therefore, are quite effective in reducing allergy signs and symptoms, especially if they are administered before contact with the relevant antigen; however they are not effective in treating asthma. Their effects vary widely, both among the drugs and from individual to individual; in young children excitement may be seen. Another common set of effects caused by many of these drugs, including dry mouth, blurred vision, and urinary retention, can be ascribed to their anticholinergic actions. H-1 receptor antagonists have low toxicity. The chief adverse effect is sedation. Overdoses of H-1 receptor antagonists may be associated with excitement or depression, and although there is no pharmacologic antidote for these drugs, good supportive care should be adequate in managing cases of poisoning. See Allergy, Antigen-antibody reaction

H-2 receptor antagonists are much newer. Histamine stimulates gastric acid secretion by combining with H-2 receptors. By preventing this combination, H-2 antagonists can reduce acid secretion in the stomach, an effect that makes these drugs useful in managing various conditions, such as peptic ulcer disease.

Other conditions in which H-2 antagonists are used to lower gastric acidity include reflux esophagitis, stress ulcers, and hypersecretory states such as the Zollinger-Ellison syndrome, in which tumor cells secrete large amounts of the hormone gastrin, which stimulates gastric acid secretion. In these conditions, administration of H-2 antagonists reduces symptoms and promotes healing.

The toxicity of H-2 antagonists is quite low, and adverse effects are reported by only 1-2% of patients. The most common side effects are gastrointestinal upsets, including nausea, vomiting, and diarrhea.


A drug that prevents or diminishes the effect of histamine; used in treating allergic reactions and common-cold symptoms.


any drug that neutralizes the effects of histamine, used esp in the treatment of allergies
References in periodicals archive ?
MP29-02 (Intranasal Formulation of Azelastine Hydrochloride and Fluticasone Propionate) in the Treatment of Ocular Symptoms of Seasonal Allergic Rhinitis (SAR).
In this study, Dymista was compared to placebo (same vehicle as Dymista minus azelastine and fluticasone), azelastine hydrochloride monotherapy (in the Dymista vehicle) and fluticasone propionate (in the Dymista vehicle).
Dymista Nasal Spray is indicated for the relief of symptoms of seasonal allergic rhinitis in patients 12 years of age and older who require treatment with both azelastine hydrochloride and fluticasone propionate for symptomatic relief.
Results from this study are consistent with recent comparison data showing that the intranasal antihistamine azelastine hydrochloride is an effective therapeutic option for patients who fail to find satisfactory symptom relief with both prescription and over-the-counter oral antihistamines," said Craig LaForce, M.
This new data follows a study published in the August 2003 issue of Annals of Allergy, Asthma and Immunology, showing that intranasal administration of azelastine hydrochloride was an effective therapeutic option for patients who experienced unsatisfactory relief from their moderate to severe allergic rhinitis symptoms with the oral antihistamine loratadine (Claritin(R)).
10 /PRNewswire/ -- Azelastine hydrochloride (ASTELIN(R) Nasal Spray) may improve nasal congestion in patients with symptomatic seasonal allergic rhinitis, according to an open-label pilot study presented today by researchers from the Allergy and Asthma Medical Group and Research Center (AAMGRC) at the annual meeting of the American College of Allergy, Asthma & Immunology (ACAAI).