B lymphocyte

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B lymphocyte

[¦bē ′lim·fə‚sīt]
(immunology)
References in periodicals archive ?
Detection of T- and B-lymphocyte transformation rate: As shown in Table 7, compared with blank control group (Pless than 0.
It was ensured that all samples were from patients without haematological malignancies, because these patients may have leukocytes present in their peripheral blood which are not activated B-lymphocytes but are also present in the abnormal population that is reported as the "OTHERS" value (1).
In this study, we used the MTT assay to detect the proliferation activity of splenocytes after T-lymphocyte (PHA, 10 [micro]g/ml) and B-lymphocyte mitogen (LPS, 50 [micro]g/ml) stimulation.
Their B-lymphocyte stimulator (BlyS) levels and CD19+CD25+ lymphocyte percentages were determined.
Ofatumumab (Arzerra) is a fully humanized monoclonal antibody against B-lymphocyte antigen CD20, which optimizes B-cell antibody response.
Immunization that results in an IgG autoantibody response requires switching of B-lymphocyte class, and therefore CD4 T cells must be involved in addition to naive mature B cells.
According to the CDC, SCID "includes a group of rare, life-threatening disorders caused by at least 15 different single gene defects that result in profound deficiencies in T- and B-lymphocyte function," and the estimated incidence among infants in the United States is approximately 40-100 cases each year.
Belimumab targets and inhibits soluble B-lymphocyte stimulator (BLyS), a protein that is overexpressed in SLE.
Mitogens chosen in the lymphocyte proliferation assay were phytohemagglutinin (PHA) and concanavalin A (ConA) for T-lymphocyte stimulation, and lipopolysaccharide (LPS) and phorbol 12,13-dibutyrate (PDB) for B-lymphocyte stimulation.
LymphoStat-B, a human monoclonal antibody that specifically recognizes and inhibits the biological activity of B-lymphocyte stimulator (BLyS), is in clinical development as a potential treatment for rheumatoid arthritis and systemic lupus erythematosus (SLE).