beta oxidation

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beta oxidation

[′bād·ə äks·ə′dā·shən]
(biochemistry)
Catabolism of fatty acids in which the fatty acid chain is shortened by successive removal of two carbon fragments from the carboxyl end of the chain.
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The enzymes for the b-oxidation oflong- to mediumchain fatty acids (C-18 to C-12) are located close to the inner mitochondrial membrane, they are: very-longchain acyl-CoA dehydrogenase, long-chain enoyl-CoA hydratase, long-chain L 3-hydroxyacyl-CoA dehydrogenase and long-chain 3-ketoacyl-CoA thiolase.
The altered b-oxidation is followed by the accumulation of representative acylcarnitines depending on the type of enzymatic deficiency in the pathway (1).
The main function of carnitine is to shuttle activated long-chain fatty acids [fatty acylcoenzyme A (CoA)] from the cytosol into the mitochondrial matrix for b-oxidation, and to remove short-chain, medium-chain and long chain fatty acids, that accumulate as a result of normal and abnormal metabolism (37).
Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial ayl-CoA dehydrogenase gen product, is a rate-limiting enzyme in long-chain fatty acid b-oxidation system.