The foundational understanding of BAG3
mutations and the company's gene therapy product are based on 10 years of research performed by Dr.
expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner," Journal of Biological Chemistry, vol.
The three-dimensional structures of Mus musculus BAG3
BD (PDB ID: 1uk5A) and ubiquitin domain (PDB ID: 1v86) were chosen as templates by which three-dimensional structures for BAG and ubiquitin domain of ZmBAG1 proteins were predicted.
There were three unique proteins to the 240 minutes TCDD treatment AHR-TAP samples, Bcl2-associated athanogene 3 (Bag3
), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2), and ubiquitin associated protein2-like(Ubap2l)(Figure 5).
Our data reveal that [E.sub.2] induces the expression of anti-apoptotic genes (BAG2, BAG3
, DAD1) while simultaneously down-regulating the expression of pro-apoptotic genes (CASP2, NIX; Figure 6D).
In nonsyndromal CVD, an exonic deletion in the BAG3
(BCL2-associated athanogene 3) gene has been related to dilated cardiomyopathy in a multigenerational family with autosomal dominant transmission of the disease (24).