is required for NF[KAPPA]B nuclear translocation by both canonical and non-canonical pathways and for NIK phosphorylation.
As shown in Figure 4(a), [kappa]-carrageenan alone mediated a slight nonstatistical increase in the expression of Bcl10
, the phosphorylation of I[kappa]B[alpha], and the nuclear expression of [NF-[kappa]B in HT-29 cells at high doses (P > 0.05).
Tobacman, "Carrageenan-induced NF[kappa]B activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10
," Biochimica et Biophysica Acta--General Subjects, vol.
Interestingly, DNA-chip hybridization assays identified both BCL-6 and BCL10
as novel candidate genes in pancreatic cancer that were overexpressed in pancreatic cancer cell lines and primary tumor samples .
Researchers at the University of Michigan Health System have learned that a key protein called Bcl10
is needed for the free fatty acids, which are found in high-fat food and stored in body fat, to impair insulin action and lead to abnormally high blood sugar.
Using miRGen and MicroCosm, we found that Ccna2 and Bcl10
, two genes that were up-regulated in our mRNA arrays, were the predicted targets of the down-regulated rno-miR-489 and rno-let-7e*, respectively.
The rogue gene, labelled Bcl10
, was originally thought to be implicated only in a rare cancer called B cell non-Hodgkin's lymphoma.
O'Rourke et al., "Bcl10
activates the NF-[kappa]B pathway through ubiquitination of NEMO," Nature, vol.
Immunohistochemically, acinar cell carcinomas are positive, with different frequencies, for trypsin, chymotrypsin, BCL10
, and lipase.
In addition, interaction of DPP4 with caveolin-1 may form a complex consisting of DOO4, CARMA1, Bcl10
, MALT1, and I[kappa]B kinase in the lipid rafts on T cell membrane, leading to the activation of NF-[kappa]B .
Herit et al., "The NF-[kappa]B Signaling Protein Bcl10
Regulates Actin Dynamics by Controlling AP1 and OCRL-Bearing Vesicles," Developmental Cell, vol.