bcl-2

(redirected from BCL2)
Also found in: Medical, Acronyms.

bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
positivo: vimentina (100%), CD34 (85%), BCL2 (65%) y CD99 (40%).
In 14 of 18 patients, breaks in both JH and DH segments were observed in the IGH locus, together with a single break in BCL2, consistent with aberrant D-J recombination leading to a translocation between chromosomes 14 and 18.
The expression of BCL2 gene is dependent on endogenous and environmental stimuli that regulate the results of transcription and posttranscriptional levels.
(11.) Miyashita T, et al., Tumor suppressor P53 is a regulator of BcL2 and 8ax gene expression in vitro and in vivo.
Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.
A continuacion, se recurrio a la prueba exacta de Fisher para analizar la asociacion estadistica entre el marcado por BCL2 y las variables localizacion, grado de diferenciacion histologica, estadificacion y pronostico.
Others have reported that BCL2 gene which was significantly upregulated may play a role in the mechanism of the drug resistance induced by MSCs in the leukemic cells.
Rigorous analysis of clustering shows that 60 genes were coexpressed (AKT1, BAD, BAX, BCL2, BDNF, CASP3, CASP8, CASP9, MYC, PIK3CD, MAPK1, MAPK10, and CYCS).
Similarly, PPAR[alpha] serves as E3 ligase to induce Bcl2 ubiquitination and degradation leading to increased cancer cell apoptosis in response to chemotherapeutic agents [6].
BAX and BCL2 are two members of a gene family involved in the regulation of cellular apoptosis.