bcl-2

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bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
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The BCL2 is thought to regulate apoptosis and has been found to be active in other types of cancer.
Reduced expression of MAD2, BCL2, and MAP kinase activity in pig oocytes after in vitro aging are associated with defects in sister chromatid segregation during meiosis II and embryo fragmentation after activation.
21] Human genes: BCL2, B-cell CLL/lymphoma 2; MCL1, myeloid cell leukemia sequence 1 (BCL2-related).
Microscopically, the tissue was substantially infiltrated by an atypical lymphoid infiltrate positive for CD20, BCL2, CD5 (weakly), κ light chain and cycline D1, consistent with mantle cell lymphoma (Fig.
Also, BCL2 positivity was found in most of the tumor cells.
In a stage III breast cancer with a tumor of 3 cm wide and metastases, usually the angiogenic mechanism is strongly active associated with overexpressed BCL2, increasing resistance to chemotherapy (www.
Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocations.
After intravenous injection, PNT2258 achieves systemic distribution, delivering PNT100 into the nuclei of cancer cells where it is designed to target and interfere with the regulatory region of the BCL2 oncogene.
Basal cell adenocarcinomas have been known to express p53, BCL2, and epidermal growth factor receptor (9).
For example, a high percentage of IGH/ BCL2 fusions on the section with H/DS but with no immunohistochemical evidence of B-cell lymphoma would confirm that H/DS harbors the cytogenetic abnormality.