bcl-2

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bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
References in periodicals archive ?
In our opinion, a minimal IHC panel for FL should include BCL2, CD3, CD10, and CD20; however, ideally, BCL6, CD5, and CD21 should be included as well.
La proteina BCL2 se detecto en 95% de los casos (22).
Along with the diagnosis, there is an increasing need to evaluate prognostic markers like CD10, BCL2, BCL6 and MUM1 to subcategorize DLBCL into Germinal Centre (GC) type or Activated B Cell (ABC) type as they have different survival rates.
Of clinical importance, they noted that sabutoclax, which suppresses all BCL2 anti-apoptotic proteins, renders these marrow-dwelling blast crisis LSCs sensitive-and more susceptible-to TKI-based therapeutics at doses that do not harm normal progenitor cells.
Fluorescence in-situ hybridization studies (FISH) for abnormalities of the MALT, BCL2, and BCL6 loci in the parotid tumor were negative.
3 In one study of 10 pilomatricoma lesions, all immunostaining results were strongly positive for BCL2.
BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma.
So cells need just the right amount of BCL2 to keep from killing themselves unnecessarily, but not so much of it that they can never die.
In difficult cases, fluorescent in situ hybridisation analysis for breakpoints in MYC, BCL2 and BCL6 loci should be undertaken.