cDNA aliquots were then utilized in qPCR reactions for BAX and BCL2
and VEGF165b with TBP, RPLP0 and TFRC used as the endogenous reference genes.
positivo: vimentina (100%), CD34 (85%), BCL2
(65%) y CD99 (40%).
In 14 of 18 patients, breaks in both JH and DH segments were observed in the IGH locus, together with a single break in BCL2
, consistent with aberrant D-J recombination leading to a translocation between chromosomes 14 and 18.
The expression of BCL2
gene is dependent on endogenous and environmental stimuli that regulate the results of transcription and posttranscriptional levels.
(11.) Miyashita T, et al., Tumor suppressor P53 is a regulator of BcL2
and 8ax gene expression in vitro and in vivo.
Concurrent expression of MYC and BCL2
in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.
A continuacion, se recurrio a la prueba exacta de Fisher para analizar la asociacion estadistica entre el marcado por BCL2
y las variables localizacion, grado de diferenciacion histologica, estadificacion y pronostico.
Others have reported that BCL2
gene which was significantly upregulated may play a role in the mechanism of the drug resistance induced by MSCs in the leukemic cells.
is present on chromosome 18 at location 18q21.33.
Rigorous analysis of clustering shows that 60 genes were coexpressed (AKT1, BAD, BAX, BCL2
, BDNF, CASP3, CASP8, CASP9, MYC, PIK3CD, MAPK1, MAPK10, and CYCS).
Similarly, PPAR[alpha] serves as E3 ligase to induce Bcl2
ubiquitination and degradation leading to increased cancer cell apoptosis in response to chemotherapeutic agents .
BAX and BCL2
are two members of a gene family involved in the regulation of cellular apoptosis.