BRCA gene

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Related to BRCA gene: BRCA2 gene, Lynch syndrome

BRCA gene:

see breast cancerbreast cancer,
cancer that originates in the breast. Breast cancer is the second leading cause of cancer death in women (following lung cancer). Although the vast majority of the cases occur in women, some men also get breast cancer.
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References in periodicals archive ?
It also substantially reduces the risk for ovarian cancer, which is elevated among this population of patients, even among those without a deleterious BRCA gene mutation.
The Food and Drug Administration approved AstraZeneca PLC's Lynparza for patients with inherited BRCA gene mutations who have undergone chemotherapy, the FDA said in a statement.
Susan Ross, from Whitley Bay, who was first diagnosed with ovarian cancer with a BRCA gene mutation 10 years ago, was part of a clinical trial of rucaparib at the Northern Centre for Cancer Care in Newcastle.
Dundee mum Aimi, who had her breasts removed after learning she had the rogue BRCA gene, said: "The giggling and laughing stops quickly when people realise how serious the message is.
Much current research into breast cancer diagnostics and therapeutics has focused on three types of the disease: triple-negative cancer, cancer that is linked to HER2 gene amplification, and cancer that is linked to BRCA gene mutations.
It wasn't until my cousin Marilyn phoned to say she had been diagnosed with breast cancer and the BRCA gene and that her genetic counsellor had suggested that all the family should be tested, that I took notice.
This new class of medications is most effective in ovarian cancer patients who have a mutation in the BRCA gene, and is administered orally.
Bruno Rosset, CEO and founder of Just4Me Genetics, said: "If you have a BRCA gene that is not working properly, meaning, it carries a harmful mutation, your risk of developing breast, ovarian and other cancers increase significantly.
While all women with a BRCA gene mutation are given this same risk figure of 87%, it is actually much more complex and different for every person.
Goldberg says that in general, one of 800 people carries this gene abnormality but for Ashkenazi Jews like him, the risk of a BRCA gene mutation is higher at one out of 40 individuals.
And what about a patient who has a BRCA gene mutation, is her risk altered by her genetic mutation?
Christina Applegate and Angelina Jolie opted for full mastectomies after testing positive for a BRCA gene mutation.