FAD

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Related to BRCA2: BRCA1

FAD

FAD

["FAD, A Simple and Powerful Database Language", F. Bancilon et al, Proc 13th Intl Conf on VLDB, Brighton, England, Sep 1987].
References in periodicals archive ?
RDx testing can determine inherited gene mutations that influence breast cancer, including BRCA1 and BRCA2, as well as TP53, PTEN, STK11, CDH1, PALB2, CHEK2, ATM, NBN, BARD1 and BRIP1.
All coding exons and adjacent intronic splice junction regions of BRCA1 and BRCA2 genes were screened for mutations in fragments between 197 to 823 bp length for Sanger Sequencing and about 450 bp length for Next Generation Sequencing (NGS) using a Multiplicome BRCA MASTR Dx Kit, which has a CE-IVD certificate in the MiSeq Illimuna Platform.
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies.
Although NGS is an efficient method for BRCA1 and BRCA2 mutation screening, many other genes need to be detected in HBOC cases.
In some cases genetic mutations in BRCA1 and BRCA2 are inherited, which may generate uncontrolled proliferation of a single cell and contribute to the development of cancer (7).
The study discovered that, although the mutations had not been inherited, many breast cancer patients had mutational signatures that were identical to those with faulty BRCA1 and BRCA2 genes.
All individuals gave written informed consent for BRCA1 and BRCA2 testing.
As a result, there is a pressing need to find new approaches and strategies; of these, targeted therapies hold particular promise, and BRCA2 is one such therapy that has great potential.
To help clarify the issue, investigators at nine comprehensive cancer centers enrolled 627 women with BRCA1 mutations, 453 with BRCA2 mutations, and 3 with mutations in both genes who underwent RRSO without either prior or concomitant hysterectomy.
The NEXTflex BRCA1 and BRCA2 Amplicon Panels are complete kits that include all components necessary for rapidly generating ready-to-sequence libraries, including primer pairs, library prep reagents, size selection beads, and indexed barcodes.
BRCA1 and BRCA2 are the major genes associated with hereditary breast cancer susceptibility [3, 4].
El sindrome de cancer hereditario de mama y ovario (SCHMO) es una condicion que aumenta la probabilidad de desarrollar cancer de mama, ovario y de otros tipos de cancer como pancreas y prostata, debido a la presencia de mutaciones germinales en los genes de susceptibilidad BRCA1 o BRCA2 localizados en el cromosoma 17q21 (1) y 13q12-q13 (2) respectivamente (3-6).