Barr body


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Related to Barr body: Pseudoautosomal region

Barr body

[′bär ‚bäd·ē]
(cell and molecular biology)
A condensed, inactivated X chromosome inside the nuclear membrane in interphase somatic cells of women and most female mammals. Also known as sex chromatin.
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8 The Barr body examination helpful in determination of the sex not only of the adult but also of the foetus in the utero.
Open Committee required all female competitors to verify their gender with a Barr body test, which looks for the presence of two X chromosomes in a somatic cell to prove that the subject is female.
This is driven by the X-inactivation gene (XIST), which produces a noncoding RNA that covers the entire X chromosome and essentially silences it--making it inactive and condensing it into what is termed a Barr body.