Barrier Function

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Barrier Function


the ability of the human or animal organism to protect its internal environment (blood, lymph, tissue fluid) from external influences and to maintain the relative constancy (homeostasis) of its composition of chemical, physical and biological properties by means of special physiological mechanisms called barriers. External barriers (the skin, mucous membranes, and the respiratory, excretory, and digestive apparatus) are conventionally distinguished from internal barriers—histological and hematological barriers located between the blood and the tissue fluids (extracellular fluids) of organs and tissues. Among the external barriers the most important is the hepatic barrier which neutralizes poisonous compounds formed in the intestine and released by it into the blood. The barrier function determines to a large extent the life functions of organs and tissues, as well as their sensitivity to bacteria, poisons, toxins, products of a disturbed exchange of substances, foreign substances, and medicines. The plasticity of the external and internal barriers, their adaptability to changing conditions in the environment, are essential for the normal existence of the organism and its protection against disease, intoxication, and so on. The most detailed studies have been made of such barriers as the hematencephalitic barrier (between the blood and the brain), the hematophthalmic barrier (between the blood and the tissues of the eye), and the placental barrier (between the organism of the mother and the embryo). Work by Soviet scientists (such as L. S. Shtern, A. A. Bogomol’-ets, B. N. Mogil’nitskii, and A. I. Smirnovaia-Zamkovaia) has contributed greatly to knowledge of the barrier function.


Shtern, L. S. Neposredstvennaia pitatel’naia sreda organov i tkanei. Moscow, 1960.
Razvitie i reguliatsiia gistogematicheskikh bar’erov (a collection). Edited by L. S. Shtern. Moscow, 1967.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
When discussing with parents how the protective barrier functions considering the strateum corneum as a brick wall with the corneocytes as bricks and the lipids as cement can be a useful analogy to illustrate how the decreased barrier function of the corneum stratum makes an infant's skin more permeable and inclined to dryness (Elias, 1996).
(2) These loss-of-function mutations result in disruptions to skin barrier function, including abnormal corneocyte adhesion, enhanced transepidermal water loss (TEWL), and dysregulated skin pH.
The reduction or complete loss of filaggrin expression can lead to abnormal skin barrier function, which permits enhanced percutaneous transfer of allergens, and finally induces AD.
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Still according to her, "As Asians we are known to have a weak barrier function. It means when we are exposed to the sun, we are automatically prone to pigmentation, more prone to getting tan lines compared to Caucasians, and we have a higher chance of getting skin cancer."
In humans, mattrin is expressed within the cells that produce and maintain the skin's barrier function.
The 23 papers cover molecular properties of the tight junction; regulation of the tight junction and barrier function; and tight junctions in skin, lung, endothelia, and nervous tissues.
Within the SMMS nonwovens, the meltblown web assumes a barrier function without negatively affecting the breathability or surface characteristics of the finished nonwovens.
As a result, VLBW infants have increased transepidermal water loss (TEWL) and normal barrier function is delayed.
The line relies on extra virgin olive oil to reinforce the skin's natural barrier function, olive-derived squalane for intense moisturizing, olive leaf extracts for their antioxidant-dense flavonoids and olive blossom extracts for their regenerative powers.
Sunflower oil in its natural state contains significant quantities of essential fatty acids that are known to improve skin barrier function and has been used for centuries to treat skin conditions.
This epithelial barrier function can be further weakened by infection with bacteria, including S.