Barrier Function

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Barrier Function


the ability of the human or animal organism to protect its internal environment (blood, lymph, tissue fluid) from external influences and to maintain the relative constancy (homeostasis) of its composition of chemical, physical and biological properties by means of special physiological mechanisms called barriers. External barriers (the skin, mucous membranes, and the respiratory, excretory, and digestive apparatus) are conventionally distinguished from internal barriers—histological and hematological barriers located between the blood and the tissue fluids (extracellular fluids) of organs and tissues. Among the external barriers the most important is the hepatic barrier which neutralizes poisonous compounds formed in the intestine and released by it into the blood. The barrier function determines to a large extent the life functions of organs and tissues, as well as their sensitivity to bacteria, poisons, toxins, products of a disturbed exchange of substances, foreign substances, and medicines. The plasticity of the external and internal barriers, their adaptability to changing conditions in the environment, are essential for the normal existence of the organism and its protection against disease, intoxication, and so on. The most detailed studies have been made of such barriers as the hematencephalitic barrier (between the blood and the brain), the hematophthalmic barrier (between the blood and the tissues of the eye), and the placental barrier (between the organism of the mother and the embryo). Work by Soviet scientists (such as L. S. Shtern, A. A. Bogomol’-ets, B. N. Mogil’nitskii, and A. I. Smirnovaia-Zamkovaia) has contributed greatly to knowledge of the barrier function.


Shtern, L. S. Neposredstvennaia pitatel’naia sreda organov i tkanei. Moscow, 1960.
Razvitie i reguliatsiia gistogematicheskikh bar’erov (a collection). Edited by L. S. Shtern. Moscow, 1967.


References in periodicals archive ?
In preliminary clinical studies, the technology has demonstrated significantly better barrier function with substantial improvement in moisture retention when compared to commercially available sphingolipid compounds.
Dermatology research has shown that children with atopic dermatitis (eczema) have dry, itchy skin due to excessive water loss, as their skin's barrier function is suboptimal.
BIONOVA products restore skin natural barrier function, prevent premature skin wrinkling and aging, unclog skin pores and work in harmony with the skin own bioactive substances by improving the skin metabolism.
0%) blended with plant stem cell antioxidants and biomimetic proteins in an exclusively designed micronized emulsion system, Retamax aids in skin rejuvenation by triggering the natural formation of collagen and encouraging the restoration of the skin barrier function by up-regulating the production of hyaluronic acid.
Defects in the skin's barrier function play critical roles in the pathogenesis of skin diseases such as eczema, irritant contact dermatitis and other common skin disorders and may also be of importance in HIV related skin dermatoses.
The skin is subjected to various stresses on a daily basis, which lead to a deficiency' in its barrier function.
A transepidermal water loss study also revealed that Daikon Radish Oil significantly improved barrier function in comparison to isopropyl palmitate at all measurement intervals between 30 minutes and four hours post application.
BIONOVA scientists, after decades of studying the human physiology and biochemistry, came to the conclusion that the best treatment for skin is to restore links on a cellular level and to enhance the skin barrier function by using the same ingredients in the same quantities and composition produced by the body.
Similarly, in the gut, GSNO supports barrier function and maintains the integrity of the gut surface.
Reinhold Dauskardt of Stanford University will present "Biomechanics of the Barrier Function of Human Skin: Predicting Skin Damage and the Effects of Cosmetic Treatments.
7, 2011 /PRNewswire/ -- Skin's primary function is not its beauty and attractiveness but the barrier function between the environment and inner body system.
ISP) is aimed at helping the skin's own natural barrier function protect against UV rays.