Oral melanocytes are derived from neural crest stem/progenitor cells, most of which during embryogenesis migrate to their final destination in the basal cell layer
of the oral epithelium.
According to p63 immunostaining, the positivity of basal cell layer
in BPH and PAC cases were seen in 92% and 4% of cases, respectively.
On the other hand, the basal cell layer
shows good positivity (Figures 1 and 2).
Nuclei seem intensely basophilic and centrally located Z4 Dermal papillae Basal cell layer
cells have a cuboidal shape containing large rounded nuclei.
(9) Ki-67 positive cells were mostly detected in the suprabasal cell layer than the basal cell layer
. This finding is in accordance to many studies.
Histopathology (Figures 4 and 5) of the papular, polygonal lesion showed compact orthokeratosis, wedge-shaped hypergranulosis, irregular acanthosis, vacuolar degeneration of basal cell layer
and band-like upper dermal lymphocytic infiltrate.
BCC usually originate from basal cell layer
or outer root sheath of hair follicles and it is considered as an adnexal tumor in WHO classification.1 Basal cell carcinoma usually grows slowly with local invasiveness.2 Keratinocytes are recognized to be the source of SCC.
Also, the staining was restricted to the basal cell layer
in non-dysplastic leukoplakias, with an increase in suprabasal positivity as the grade of dysplasia increased.
1c) and S100, and PCNA were 1+ in the basal cell layer
. P-53 was negative.
This intraglandular proliferation is consistently surrounded by a basal cell layer
that is often attenuated and disrupted, especially in high-grade PIN.
Genomics of Epidermolysis Bullosa EB Type Level of Blistering Genes Simplex Basal cell layer
KRT5, KRT14 Hemidesmosomal Basal cell/lamina BPAG2, ITGB4, ITGA6 lucida interface (PLEC1 with muscular dystrophy) Junctional Lamina lucida LAMA3, LAMB3, LAMC2 Dystrophic Sublamina densa COL7A1 Source: Dr.
The scientists, led by Gary Halliday from the University of Sydney, wrote in the journal Proceedings of the National Academy of Sciences, 'The predominance of UVA mutations in the basal cell layer
reinforces the pivotal role UVA may play in the malignant transformation of human skin.