stratum germinativum

(redirected from Basal keratinocyte)
Also found in: Dictionary, Thesaurus, Medical.
Related to Basal keratinocyte: stratum basale

stratum germinativum

[′strad·əm ‚jər·mə·nə′tī·vəm]
(histology)
The innermost germinative layer of the epidermis.
References in periodicals archive ?
(26) Interface changes, such as vacuolar alteration of basal keratinocytes, dyskeratotic keratinocytes, and blurring of the dermal-epidermal junction by lymphoid cells, also favor LSA,26 although they have also been reported in MF.
In fact, the laminin has functional domains which can bind integrins of basal keratinocytes and type VII collagen, forming anchoring fibrils, essential to the resistance of the epidermis.
They pinpointed 55 "reprogramming factors" (proteins and RNA molecules) that were potentially involved in defining the distinct identity of the basal keratinocytes. Then, through trial and error and further experiments on each potential reprogramming factor, they narrowed the list down to four factors that could mediate the conversion to basal keratinocytes.
It is possible that in drug-induced lichen planus/ lichenoid reaction, CD8+ T cells may be activated by a drug molecule expressed by basal keratinocytes in association with MHC class I molecules and that the activated cytotoxic CD8+ T cells may trigger necrosis or apoptosis of keratinocytes via the Fas-Fas L, granulysin, or perforin/granzyme pathways [23, 42, 43].
Electron microscopy of the hyperpigmented areas shows plenty of melanosomes within the basal keratinocytes and disorganization of the keratin filaments.
Furthermore, histopathological examination of targetoid lesions reveals orthohyperkeratosis, keratotic plugging, basal cell vacuolar degeneration with colloid bodies, necrotic basal keratinocytes, perivascular and periadnexal lymphocytic infiltrates, melanin incontinence and dermal mucin deposition, consistent with LE.
Injury to the basal keratinocytes and other structures produce tiny vacuoles along the dermoepidermal junction on both sides of the basal lamina known as vacuolar alteration or vacuolization.
Virus infects basal keratinocytes probably via micro-abrasions of the epithelial surface that leave the basal lamina intact (2).
Plectin abnormality in epidermolysis bullosa simplex Ogna: non-responsiveness of basal keratinocytes to some anti-rat plectin antibodies.
"In nonlesional basal keratinocytes, there are few keratin filaments, and mitochondria are prominent," Dr.
However, under a wound stimulus, basal keratinocytes express K6b/K16 instead of K1/K10 in response to cytokines and immune mediators released during wound repair [12].
A recently reported series described the loss of-function mutations in the KRT5 gene (9,10) These data confirm that haplo in sufficiency for K5 engenders an excess of unpaired, soluble K14 that is then responsible for DDD and points to a prominent role for the keratin intermediate filament cytoskeleton within the basal keratinocytes in epidermal pigment biology.