base excision repair(redirected from Base-excision repair)
Also found in: Medical.
base excision repair[′bās ek′siz·zhən ri‚per]
A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.