base excision repair

(redirected from Base-excision repair)
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base excision repair

[′bās ek′siz·zhən ri‚per]

(cell molecular)

A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated.

Mentioned in ?

Lindahl, Tomas

References in periodicals archive ?

Egan et al., "Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer," Cancer Epidemiology Biomarkers & Prevention, vol.

Modulation of Colorectal Cancer Risk by Polymorphisms in 51Gln/His, 64Ile/Val, and 148Asp/Glu of APEX Gene; 23Gly/Ala of XPA Gene; and 689Ser/Arg of ERCC4 Gene

Ling et al., "Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection," Frontiers in Bioscience, vol.

Oxidative DNA Damage Mediated by Intranuclear MMP Activity Is Associated with Neuronal Apoptosis in Ischemic Stroke

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res 2007; 35: 390-400, doi: 10.1093/nar/gkl1052.

DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

Excision of the U residue from DNA produces an abasic site, leading to incision of the DNA strand containing the abasic site by the conventional base-excision repair pathway.

APOBEC: Enzymatic DNA deamination and the immunity/cancer balance

Germline susceptibility to colorectal cancer due to base-excision repair gene defects.

Multiplex tetra-primer amplification refractory mutation system PCR to detect 6 common germline mutations of the MUTYH gene associated with polyposis and colorectal cancer

Comparison of base-excision repair capacity in proliferating and differentiated PC 12 cells following acute challenge with dieldrin.