base excision repair

(redirected from Base-excision repair)
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base excision repair

[′bās ek′siz·zhən ri‚per]
(cell molecular)
A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated.
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References in periodicals archive ?
Egan et al., "Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer," Cancer Epidemiology Biomarkers & Prevention, vol.
Ling et al., "Impaired DNA repair via the base-excision repair pathway after focal ischemic brain injury: a protein phosphorylation-dependent mechanism reversed by hypothermic neuroprotection," Frontiers in Bioscience, vol.
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res 2007; 35: 390-400, doi: 10.1093/nar/gkl1052.
Excision of the U residue from DNA produces an abasic site, leading to incision of the DNA strand containing the abasic site by the conventional base-excision repair pathway.
Comparison of base-excision repair capacity in proliferating and differentiated PC 12 cells following acute challenge with dieldrin.