Basal Membrane

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basal membrane

[′bā·səl ′mem‚brān]
The tissue beneath the pigment layer of the retina that forms the outer layer of the choroid.

Basal Membrane


in vertebrate animals and man, the boundary film between the epithelium (or endothelium) and underlying loose connective tissue from which it is formed. The basal membrane consists of a diffuse substance and the fibers embedded in it. It serves to strengthen the epithelial layer of cells and prevents its cells from shifting deep into the connective tissue. Impairment of the basal membrane causes the epithelium to grow into the underlying connective tissue (for example, in chronic inflammation and malignant degeneration). The fact that the basal membrane is permeable to some metabolites indicates that it plays a definite part in metabolism.

References in periodicals archive ?
It is possible that the potassium channel repertoire of the basolateral membrane indirectly contributes to the observed variety in responses to [H.
The general finding of Aqp3 protein in the basolateral membrane of chloride cells suggests that this aquaporin is participating in cell volume regulation and may take part in nitrogen excretion as well.
In the kidney, GLUT2 is located in the basolateral membrane where it participates in the release of reabsorbed glucose (Wright et al.
1990), suggest that OAT1 and OAT3 activities localized at the basolateral membrane, which mediate the entries of several endogenous and exogenous substances into the proximal tubule cells, can be influenced earlier by cholesterol accumulation than the effluxing transporters localized apically.
This protein is responsible for iron export from the basolateral membrane of entercytes and release of iron from hepatocytes and macrophages.
The mRNA mediates translation of specific proteins that increase the activity and/or number of the luminal membrane sodium channels and basolateral membrane [Na.
In thyroid cells, iodide uptake occurs across the basolateral membrane and is driven by an inwardly directed [Na.
The amount of AQP6vs located in the basolateral membrane varied between specimens; AQP6vs was scarcely detectable in some cases, but was abundantly observed in others.
In well-differentiated tumors, RAAG12 expression was observed on apical membrane surfaces together with basolateral membrane expression.
Fructose can also cross the basolateral membrane via the activity of GLUT2 (Cheeseman, 1993).