Basophilia


Also found in: Dictionary, Thesaurus, Medical.

basophilia

[‚bās·ə′fil·ē·ə]
(biology)
An affinity for basic dyes.
(medicine)
An increase in the number of basophils in the circulating blood.
(pathology)
Stippling of the red cells with basic staining granules, representing a degenerative condition as seen in severe anemia, leukemia, malaria, lead poisoning, and other toxic states.

Basophilia

 

the ability of cell structures to be stained by basic dyes (pyronine, methylene blue, methylene azure, and others). Basophilia is caused by the acid components of the cell, chiefly ribonucleic acid (RNA). An elevated basophilia is found in cells which are actively synthesizing proteins and for this reason contain a great deal of RNA. Examples of such cells would be growing cells and those undergoing division (for example, embryonic and tumorous cells and cells of the hematopoietic and regenerating tissues), cells forming a protein secretion (for example, the cells of the pancreas or liver), and cells which are intensively replacing their own protein (for example, nerve cells).

From the change in basophilia, it is often possible to judge the change in the intensity of protein biosynthesis in the cell. More precise indicators of this process are determined by the autoradiographic and cytophotometric methods. Characteristic basophilia or acidophiu’a of cell structures is used for distinguishing blood cells, for analyzing cells from the anterior lobe of the pituitary body and the insular tissue of the pancreas, and so forth.

V. IA. BRODSKII

References in periodicals archive ?
Such lesions exhibited marked cell basophilia and prominent nuclei with an evident nucleoli.
Both types of cells differ in size and basophilia from the small, oval nuclei of hemocytes that circulate through the hemolymph space between adjacent air pockets of the book lung (Fig.
A comparative study of cytoplasmic basophilia and the population density of ribosomes in the secretory cells of mouse seminal vesicle.
Basophilia is often prominent and is very helpful in separating this disorder from other causes of leukocytosis.
The principal histologic change observable in fetal organs after death is disappearance of nuclear basophilia, or staining characteristics The pathologist tests for this loss using a process that stains the cell Because the nucleus disintegrates when a cell dies, there will be less basophilia staining present in a dead cell than in a living one.
Ageing of the syncytium is characterised by thinning, basophilia and increased affinity of acid dyes.
The morphologic assessment should include looking for blasts, basophilia, and granulocytic left shift, which could indicate AML, ALL, or CML.
Severe leaukocytosis, neutrophilia, monocytosis, eosinophilia and basophilia were recorded in positive camels as compared to non infected camels.
ETV6-ACSL6 fusion is a rare abnormality that is associated with myeloproliferative disorders, myelodysplasia, or acute myeloid leukemia with eosinophilia or basophilia.
Eosinophilia and basophilia may be expected with envenomation hypersensitivity (14-17) but were not observed in this case.
The cytoplasm of these cells appears basophilia and stains with eosin and their nucleus are elongated near to basal surface (Shown as Figure 3A and B).