Basophilia


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basophilia

[‚bās·ə′fil·ē·ə]
(biology)
An affinity for basic dyes.
(medicine)
An increase in the number of basophils in the circulating blood.
(pathology)
Stippling of the red cells with basic staining granules, representing a degenerative condition as seen in severe anemia, leukemia, malaria, lead poisoning, and other toxic states.

Basophilia

 

the ability of cell structures to be stained by basic dyes (pyronine, methylene blue, methylene azure, and others). Basophilia is caused by the acid components of the cell, chiefly ribonucleic acid (RNA). An elevated basophilia is found in cells which are actively synthesizing proteins and for this reason contain a great deal of RNA. Examples of such cells would be growing cells and those undergoing division (for example, embryonic and tumorous cells and cells of the hematopoietic and regenerating tissues), cells forming a protein secretion (for example, the cells of the pancreas or liver), and cells which are intensively replacing their own protein (for example, nerve cells).

From the change in basophilia, it is often possible to judge the change in the intensity of protein biosynthesis in the cell. More precise indicators of this process are determined by the autoradiographic and cytophotometric methods. Characteristic basophilia or acidophiu’a of cell structures is used for distinguishing blood cells, for analyzing cells from the anterior lobe of the pituitary body and the insular tissue of the pancreas, and so forth.

V. IA. BRODSKII

References in periodicals archive ?
Kundi et al., "Evaluation of the prognostic significance of eosinophilia and basophilia in a larger cohort of patients with myelodysplastic syndromes," Cancer, vol.
In the current study, hemato-biochemical analysis revealed mild normocytic normochromic regenerative anemia, normocytic hypochromic anemia and macrocytic-normochromic anemia, slightly elevated WBC count (in all cats) with mild basophilia and monocytosis.
Eosinophilia and sometimes basophilia in growing and adult animals may be indicative of an allergic response to recent parasitic infection [14].
Early stage (Pol) (Figure lb, white arrow): cytoplasm begins to develop and reveals strong basophilia. In the nucleus, chromatin is nuclear.
That is, some cells may be markedly reduced in size but retain slight basophilia of the nucleus, whereas the shrunken cells in other areas will exhibit nuclei which are even more diminutive and so pale as to be barely visible.
The regenerative pit bases are characterized by mucin loss, cytoplasmic basophilia, increased mitoses, and hyperchromatic nuclei that are sometimes severe enough to mimic dysplasia.
The marked basophilia of the cytoplasm is due to an abundance of rough endoplasmic reticulum.
Section of brain showing ischemia induced changes like loss of basophilia due to necrosis of the small neurons of the granular layer of brain in ischemic control group.
Dysplastic lesions are characterized by proliferative phenomenon, gland crypts with enlarged lumens, marked cell basophilia, goblet cells depletion and polarity loss (15).
The cells circulating in the peripheral blood can be characterized by nuclear-cytoplasmic asynchrony, visualized most often by a persistence of basophilia in the cytoplasm of cells with nuclei that appear to be more mature.
The significant increase in basophilia in summer indicated severe stress condition in normal birds similar to the findings of Altan et al.
In the nuclei of almost all neurons there is a weakening pattern of chromatin, they lose their basophilia and look like white spots, in which the remnants of various configurations of chromatin are found only in some places.