bcl-2

(redirected from Bcl-2 gene)
Also found in: Medical.

bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Bax and Bcl-2 gene expression intensities were represented by the ratio of their absolute copy number to [beta]-actin absolute copy number to correct the effect of RNA quantitative, reverse transcription and PCR reaction.
To study the effect of 2DG, metformin, and their combination on p53 and Bcl-2 gene expression, 1x[10.sup.6] cells/well were treated in a 6-well plate with 5 mM metformin and/or 500[micro]M 2DG for 48 hours.
The purpose of this study was to identify a polymorphism in the promoter region (-938C>A) of the BCL-2 gene. Many types of cancers are affecting the health of the global population and leukemia is considered to be one of the most damaging blood cancers.
Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.
This observations agree with our findings in the Bcl-2 gene and with decreasing the total cells of blastocyst in same group.
A scientific report has indicated that spermine also has protective effects against B cell antigen receptor-mediated apoptosis through upregulating Bcl-2 gene expression and down-regulating caspase mRNA abundance in rats [7].
Results revealed that increasing concentration of FA down regulated the anti-apoptotic Bcl-2 gene as evidenced by dose dependent decreased protein expression (Figure 6).
The Bcl-2 gene family is recognized as containing the most important set of genes with respect to mediation of apoptosis.[18],[19] Bcl-2 is a protein that inhibits cell apoptosis, while Bax is a protein that promotes cell apoptosis.
Bcl-2 gene family is known to regulate the mitochondrial changes including modulation the permeability of the mitochondrial membrane and release of cytochrome C during apoptosis [38].
Eckhoff et al., "Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene," Annals of Surgery, vol.
The expression of Bcl-2 gene in the treated MCF-7 cells was found to be dramatically downregulated by 2.18-fold and 4.9-fold, after treatment with I[C.sub.50] and I[C.sub.75] value.