bcl-2

(redirected from Bcl-2 gene)
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bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
References in periodicals archive ?
The Bcl-2 gene family is recognized as containing the most important set of genes with respect to mediation of apoptosis.
70) The loss of P53 function not only deregulates survivin gene expression but also BCL-2 gene expression with a stronger anti-apoptotic mechanism.
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor- deprived hemopoietic cell lines.
Densitometry results for ALDH2, Bax, and Bcl-2 gene were compared with corresponding [beta]-actin levels to account for loading differences.
Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma.
Tsambaos, "Reduced expression of the antiapoptotic proteins of Bcl-2 gene family in the lesional epidermis of patients with Darier's disease," Journal of Cutaneous Pathology, vol.
Methods: To study the effects of Pt-AZT on hepatocellular carcinoma and compare its effects with AZT in inhibition of telomerase and Bcl-2 gene expression, pathogen-free male Wistar rats (n=100) were used.
55[degrees]C/1 min, 72[degrees]C/1 min and a final extension of 72[degrees]C/10 min for [beta]-Actin and Bcl-2 gene.
The main purpose of the BCL-2 gene is to keep cells alive, so when the gene is silenced, cancer cells become more vulnerable to chemotherapy," says Dr.
Clinical significance of bcl-2 gene expression in human breast cancer tissues, Breast Cancer Res.
Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care.