bcl-2

(redirected from Bcl-2 protein)
Also found in: Medical.

bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Bax and Bcl-2 protein expression: One hundred milligrams intestinal tissue obtained from all the experimental dogs was grinded into liquid form, and the supernatant was separated by centrifugation for 10 min at 12,000 RPM in 4AdegC.
The Company is also developing BP1002, which targets the Bcl-2 protein and is expected to be evaluated for the treatment of lymphoma and solid tumors.
* Induced apoptosis by activating caspase-3 and caspase-9, increased BAX and p53 proteins expression and downregulated Bcl-2 protein expression.
The BCL-2 protein family: Opposing activities that mediate cell death.
Bcl-2 protein, an apoptosis regulator, can protect cells from undergoing apoptosis by preventing a caspase-3-dependent proteolytic cascade.
However, at this concentration of eugenol treatment, although there occurs significant depletion in the level of bcl-2 protein together with enhanced cytochrome c release, no notable effect has been noticed in the cleavage of procaspase-8 [6].
Antiapoptotic effect of Bcl-2 protein has been reported to be so because of Bcl-2 possessing four BH domains [5].
[10] reported that in the T1M rat model, 3 weeks after STZ administration, Bax and cytochrome C protein expressions were higher in the diabetic heart, while the Bcl-2 protein expression was similar between normal and diabetic rats; the results were in accordance with ours.
Twenty colonies each of the cells transfected with pCMV-Bcl-2 or pcDNA3 were harvested, and Bcl-2 protein expression was confirmed by western blot.
But whether the increase of Bax and decrease of Bcl-2 protein in the PLA-treated NCI-H292 cells were through ERK1/2 signal remains unclear, so we inhibited the ERK1/2 by PD98059.
Bcl-2 protein in the cytoplasm acts as inhibitor of apoptosis while Bax promotes apoptosis.32