Abbreviations: NSCLC, non-small cell lung cancer; MOMP, mitochondrial outer membrane permeabilization; PARP, poly (ADP-ribose) polymerase; Bax, Bcl-2-associated X protein
; FasL, Fas ligand; FADD, Fas-associated protein with the death domain.
Antibodies against cytokeratin 18, p53 upregulated modulator of apoptosis- (PUMA-) [alpha], B-cell lymphoma- (Bcl-) 2, Bcl-2-associated X protein
(Bax), and a SIRT1 activity assay kit were obtained from Abcam (Cambridge, UK).
The truncated form of BID acts to inhibit the Bcl-2-Bcl-xl pathway and to promote activation of Bcl-2-associated X protein
and Bcl-2 homologous antagonist killer, thereby inducings cytochrome C release, leading to formation of the apoptosome (16).