Pollak, "Renal handling and pathophysiology of
Bence Jones proteins," Contributions to Nephrology, vol.
Restricted electrophoretic heterogeneity of immunoglobulin light chains in urine: cause for confusion with
Bence Jones protein. Clin Chem.
The control
Bence Jones protein had 2 molecular species that were consistent with monomer and dimer in the presence or absence of physiologic concentrations of salt.
Correlation of serum immunoglobulin free light chain quantification with urinary
Bence Jones protein in light chain myeloma.
Correlation of serum immunoglobulin free light chain quantitation with urine
Bence Jones protein in light chain myeloma [Technical Brief].
This albuminous urine had already been fully described in clinical terms by William McIntyre (1791-1857) (89), but the significance of the
Bence Jones proteins remained obscure for more than a century.
Urine
Bence Jones proteins was negative and serum electrophoresis pattern was normal in all subjects.
Further investigations revealed that
Bence Jones proteins were absent from the urine, and an analysis of serum immunoglobulins found no monoclonal paraproteins.
In some cases myeloma cells secrete immunoglobulins that contain only the light chains, these are secreted in the urine and are known as
Bence Jones proteins (2).
Quantitative assays can have improved sensitivity for immunoglobulins and
Bence Jones proteins (4, 5).