Bence-Jones protein

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Bence-Jones protein

[¦bens ¦jōnz ¦prō‚tēn]
(pathology)
An abnormal group of globulins appearing in the serum and urine, usually in association with multiple myeloma and characterized by coagulation at 50-60°C.
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References in periodicals archive ?
Pollak, "Renal handling and pathophysiology of Bence Jones proteins," Contributions to Nephrology, vol.
Restricted electrophoretic heterogeneity of immunoglobulin light chains in urine: cause for confusion with Bence Jones protein. Clin Chem.
The control Bence Jones protein had 2 molecular species that were consistent with monomer and dimer in the presence or absence of physiologic concentrations of salt.
Correlation of serum immunoglobulin free light chain quantification with urinary Bence Jones protein in light chain myeloma.
Correlation of serum immunoglobulin free light chain quantitation with urine Bence Jones protein in light chain myeloma [Technical Brief].
This albuminous urine had already been fully described in clinical terms by William McIntyre (1791-1857) (89), but the significance of the Bence Jones proteins remained obscure for more than a century.
Urine Bence Jones proteins was negative and serum electrophoresis pattern was normal in all subjects.
Further investigations revealed that Bence Jones proteins were absent from the urine, and an analysis of serum immunoglobulins found no monoclonal paraproteins.
In some cases myeloma cells secrete immunoglobulins that contain only the light chains, these are secreted in the urine and are known as Bence Jones proteins (2).
Quantitative assays can have improved sensitivity for immunoglobulins and Bence Jones proteins (4, 5).