At diagnosis, the SPE showed small M-band in between beta and gamma regions with a quantitation of 2.8g/L, whereas the UPE showed Bence-Jones protein
of 1.1 g/L.
In about 75% of cases, free light chains are also over- produced to levels several thousands of times higher than normal and a corresponding increase in Bence-Jones protein
is measurable on urine protein electrophoresis (UPEP).
Further investigations--including Bence-Jones protein
urinalysis, skeletal survey, bone marrow aspiration, and trephine biopsy, as well as spinal MRI--revealed no evidence of myeloma.
Multiple myeloma: a plasma-cell cancer; currently incurable but treatable using various regimens; shows excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein
(free monoclonal e or e light chains).
(1,9) Often, parts of this protein are excreted by the kidneys into the urine and are known as Bence-Jones protein
. About two thirds of myeloma patients produce Bence-Jones protein
Tumor markers have been part of the clinical laboratory since the discovery of Bence-Jones protein
Urine protein electrophoresis showed generalized proteinuria and no evidence of Bence-Jones protein
. Serum protein electrophoresis showed no monoclonal band.
(7) Thus, we hypothesized that Bence-Jones protein
(BJP) quantitation by this technique is often misleading and that, instead, one may be able to use random urine protein/creatinine ratios to provide better information.
The incidence and possible relevance of Bence-Jones protein
in the sera of patients with multiple myeloma.
Light chain deposition disease or Bence-Jones myeloma is a progressive disease characterized by proliferation of plasma cells in the bone marrow and overproduction of light chain immunoglobulins (Bence-Jones proteins
) in plasma and urine .