Bence-Jones protein


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Bence-Jones protein

[¦bens ¦jōnz ¦prō‚tēn]
(pathology)
An abnormal group of globulins appearing in the serum and urine, usually in association with multiple myeloma and characterized by coagulation at 50-60°C.
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3% Laboratory results Positive M Band by serum protein 40 91% electrophoresis Urinary Bence-Jones protein 4 (28 tested) 14% Skeletal involvement Radiologically detectable 40 91% abnormalities Lytic lesions 35 80% Spine 25 71% Lumbosacral spine 24 69% Thoracic spine 12 34% Skull 23 66% Ribs 15 43% Long bones in and 12 34% Pelvis in 8 23% Clavicle in 4 11% Scapula 3 8.
8g/L, whereas the UPE showed Bence-Jones protein of 1.
Discovered more than 150 years ago, the Bence-Jones protein was the first recorded biological tumor marker.
Tumor markers have been part of the clinical laboratory since the discovery of Bence-Jones protein in 1846.
Stage Durie-Salmon Staging System I All of: Hemoglobin >10 g/dL Normal serum calcium Low concentration of M-protein (IgG <50 g/L, IgA <30 g/L, Bence-Jones protein <4 g/24hours) No bony lesions II Neither stage I nor stage III III Any of: Hemoglobin <8.
The incidence and possible relevance of Bence-Jones protein in the sera of patients with multiple myeloma.