He did well initially after starting this bortezomib-containing regimen, his routine serum protein electrophoresis showing undetectable M-protein band but persistent Bence-Jones proteinuria
in the urine protein electrophoresis.
The clinical manifestations of myeloma included anemia (100%), Bence-Jones proteinuria
(80%), "M" peak in serum electrophoresis (69%), lytic bone lesions (62%), "M" peak in urine electrophoresis (54%).
Current guidelines recommend that Bence-Jones proteinuria
be monitored with 24-hour urine collections.
Immunoglobulin light chain immunoblots of urine proteins from patients with tubular and Bence-Jones proteinuria
Common laboratory findings included anemia, slightly elevated calcium levels, lytic bone lesions, and serum monoclonal gammopathy or Bence-Jones proteinuria
Electrophoretic study of the physico-chemical characteristics of Bence-Jones proteinuria
and its association with kidney damage.
The optimum urine collections and monitoring of Bence-Jones proteinuria