In addition, urine light chain analysis revealed Bence-Jones proteinuria
with [lambda] chain level of 0.04 g/L (reference range 0 g/L) and [kappa] chain level of 0.11 g/L (reference range 0 g/L).
, autoantibodies (ANA-HEp2, cANCA, pANCA), complement and thyroid profile were within normal limits.
He did well initially after starting this bortezomib-containing regimen, his routine serum protein electrophoresis showing undetectable M-protein band but persistent Bence-Jones proteinuria
in the urine protein electrophoresis.
(1,5) In addition, over 60% of patients have monoclonal proteins in their urine (Bence-Jones proteinuria
The clinical manifestations of myeloma included anemia (100%), Bence-Jones proteinuria
(80%), "M" peak in serum electrophoresis (69%), lytic bone lesions (62%), "M" peak in urine electrophoresis (54%).
Current guidelines recommend that Bence-Jones proteinuria
be monitored with 24-hour urine collections.
Identification and quantification of Bence-Jones proteinuria
by automated nephelometric screening.