Imidazole

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imidazole

[‚im·ə′da‚zōl]
(organic chemistry)
C3H4N2 One of a group of organic heterocyclic compounds containing a five-membered diunsaturated ring with two nonadjacent nitrogen atoms as part of the ring; the particular compound imidazole is a member of the group.

Imidazole

 

(glyoxaline, 1,3-diazole) a heterocyclic base. Colorless crystals; boiling point, 256°C. Imidazole is readily soluble i n water and alcohol and moderately soluble in ether. It is aromatic, that is, readily undergoes halogenation, nitration, and sulfonation. The hydrogen of the NH group can be replaced by alkyl by the action of, for example, dimethylsulfate. Imidazole is prepared by reacting glyoxalwith ammonia and formaldehyde. Its derivatives (histamin, histidine, carnosine, pilocarpine) are widely distributed in the animal and plant worlds and have important biological significance. [10–416-6 ]

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Detection of codon for amino acid 200 in isotype 1 beta-tubulin gene of Wuchereria bancrofti isolates, implicated in resistance to benzimidazoles in other nematodes.
Many mushroom pathogens are resistant to benzimidazole fungicides or are increasingly tolerant to prochloraz.
A comparison of the interaction of anthelmintic benzimidazoles with tubulin isolated from mammalian tissue and the parasitic nematode Ascaridia galli.
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The results of a 2005 survey revealed that the Ta2 population in the southeastern region of Pennsylvania had developed formidable resistance in the three intervening years to the benzimidazoles, thiophanate-methyl and benomyl.
Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature.
More than eight sheep in every 10 in Scottish lowland flocks are showing signs of resistance to benzimidazoles.
In 2014, researchers from Brazil, Canada and the United States discovered that benzimidazoles have become largely ineffective around the world.
The introduction of benzimidazoles for alveolar echinococcosis treatment in 1976 has considerably improved the prognosis (2,3).
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