salicylic acid

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salicylic acid


2-hydroxybenzoic acid,

C6H4(OH)CO2H, a colorless, crystalline organic carboxylic acid that melts at 159°C;; it is soluble in ethanol and ether but is only slightly soluble in water. It is prepared commercially by heating sodium phenolate (the sodium salt of phenol) with carbon dioxide under pressure to form sodium salicylate, which is treated with sulfuric acid to liberate salicylic acid. Salicylic acid and its derivatives are toxic when consumed in large amounts. Sodium salicylate is used to a small extent as a food preservative and as an antiseptic in mouthwashes and toothpastes. The major use of salicylic acid is in the preparation of its ester derivatives; since it contains both a hydroxyl (−OH) and a carboxyl (−CO2H) group, it can react with either an acid or an alcohol. The hydroxyl group reacts with acetic acid to form the acetate ester, acetylsalicylic acid (see aspirinaspirin,
acetyl derivative of salicylic acid (see salicylate) that is used to lower fever, relieve pain, reduce inflammation, and thin the blood. Common conditions treated with aspirin include headache, muscle and joint pain, and the inflammation caused by rheumatic fever and
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). Several useful esters are formed by reaction of the carboxyl group with alcohols. The methyl ester, methyl salicylate (also called oil of wintergreen since it produces the fragrance of wintergreen), is formed with methanol; it is used in food flavorings and in liniments. The phenyl ester, phenyl salicylate, or salol, is formed with phenol; it is used in medicine as an antiseptic and antipyretic. This ester hydrolyzes, not in the acidic stomach, but in the alkaline intestines, releasing free salicylic acid. The menthyl ester, menthyl salicylate, which is used in suntan lotions, is formed with menthol.
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Salicylic Acid


(o-hydroxybenzoic acid), the simplest aromatic hydroxycarboxylic acid. A colorless crystalline compound that is poorly soluble in water but readily soluble in organic solvents. Melting point, 159°C; boiling point, 211°C (at 2.66 kilonewtons per sq m).

Salicylic acid is widespread in nature, especially in the form of the glycoside of its methyl ester, methyl salicylate. It is usually produced industrially by carboxylation of phenol (the Kolbe-Schmitt reaction). Salicylic acid has weak antiseptic and irritant properties and, at high concentrations, keratolytic properties. It is used topically in salve, paste, powder, and solution form for treating skin ailments. It is an ingredient of Las-sar’s paste, galmanin powder, and corn lotion and plaster. The sodium salt of salicylic acid (sodium salicylate), the amide (sali-cylamide), and acetylsalicylic acid (aspirin) are used as antipyretic, antirheumatic, anti-inflammatory, and analgesic agents. The phenyl ester of salicylic acid is used as an antiseptic, and p-aminosalicylic acid (PAS) is used as an antituberculosis drug.

Because of its antiseptic action, salicylic acid is used in the preservation of foods. Its esters are used in the manufacture of azo dyes and odoriferous substances, and the acid itself is used for the colorimetric identification of iron and copper and for the separation of thorium from other elements.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

salicylic acid

[¦sal·ə¦sil·ik ′as·əd]
(organic chemistry)
C6H4(OH)COOH White crystals with sweetish taste; soluble in alcohol, acetone, ether, benzene, and turpentine, slightly soluble in water; discolored by light; melts at 158°C; used as a chemical intermediate and in medicine, dyes, perfumes, and preservatives.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

salicylic acid

a white crystalline slightly water-soluble substance with a sweet taste and bitter aftertaste, used in the manufacture of aspirin, dyes, and perfumes, and as a fungicide. Formula: C6H4(OH)(COOH)
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Alpha and beta hydroxy acids. This group includes glycolic, lactic, citric, mandelic, tartaric and salicylic acids.
* Pads contain a precise blend of alpha- and beta hydroxy acids, antioxidants (vitamins A, C and E), soothing green tea extract and an oil-free moisturizer to give skin of any age a healthier, more vibrant appearance.
IDEAL for blemished skins as it contains AHAs - that's Alpha Beta Hydroxy Acids which have smaller molecules and penetrate to the base layer of the skin.
The most powerful substances to combat this damage, depending on the skin's affliction, are vitamin C ester (to improve fine lines, sagging or sunburned skin); alpha lipoic acid (lines, wrinkles, under-eye bags, enlarged pores, acne scars or dull skin); dimethylaminoethanol (loss of firmness, fine lines around lips, overtired skin and thin lips) and alpha and beta hydroxy acids (razor bumps, rough, dry and finely lined skin, uneven pigmentation).