beta catenin

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beta catenin

[‚bād·ə ′kat·ən·in]
(biochemistry)
A multifunctional protein that is involved in Wnt signal transduction and plays an essential role in intercellular adhesion.
References in periodicals archive ?
Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors.
The stimulation of this receptor suppresses the action of the beta-catenin protein, intercepting the series of events that change the intestinal cell into a malignant tumour cell," he added.
Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma.
Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations.
Beta-catenin is responsible for prompting osteoblasts to become mature and functional.
In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta-catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.
In the study, the fruit inhibited tumour development by suppressing a protein called beta-catenin.
The activation of beta-catenin by Wnt signaling mediates the effects of histone deacetylase inhibitors.
Regulation of these actions is exerted by a number of different coregulators including the coactivators DRIP and SRC, a less well known inhibitor, hairless, and beta-catenin.
It has been speculated [24] that these progenitor cells are resistant to radiation and that this resistance is mediated by the beta-catenin stem cell survival pathway.
One transcription factor called beta-catenin is over-active in almost all bowel cancers.