beta catenin

(redirected from Beta-catenin)
Also found in: Medical, Wikipedia.

beta catenin

[‚bād·ə ′kat·ən·in]
(biochemistry)
A multifunctional protein that is involved in Wnt signal transduction and plays an essential role in intercellular adhesion.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
A, mRNA expression levels and B, protein levels of DKK-1, beta-catenin, c-myc, cyclin D1, and survivin in HepG2 cells determined by qRT-PCR and western blot assay, respectively; C, mRNA expression levels and D, protein levels of DKK-1, beta-catenin, c-myc, cyclin D1, and survivin in SMMC-7721 cells.
Semenov et al., "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism," Cell, vol.
We have observed that, in some cases, acidophilic nuclear inclusions bear a resemblance to nuclear features seen in the BROCN tumors, morule-forming neoplasms with BROCN, which are now thought to be surrogate products of alterations in the beta-catenin pathway.
ATDC was also linked to increased levels of a signalling protein called beta-catenin, which is known to play a key role in cancer development.
Another molecule that may be involved in that death signal is beta-catenin, to which APC binds tightly.
It has two branches: the beta-catenin mediates the canonical pathway and the RhoA/PLC mediates the noncanonical pathway.
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
It was observed that cells from those without the disease had low levels of beta-catenin, a protein that enters cell nuclei and activates certain genes.
Keywords: Uncaria tomentosa Cat's claw Una de gato Wnt-signaling pathway cMyc Beta-Catenin Cancer cells