beta catenin

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beta catenin

[‚bād·ə ′kat·ən·in]
(biochemistry)
A multifunctional protein that is involved in Wnt signal transduction and plays an essential role in intercellular adhesion.
References in periodicals archive ?
Immunohistochemistry showed spindle cells with diffuse and strong nuclear and cytoplasmic reactivity for beta-catenin (figure 2, B).
Beta-catenin is the central component of this signaling pathway.
The product is an orally bioavailable small molecule, which ablates leukemic stem cells by reducing beta-catenin expression through a novel mechanism of action.
Both drugs target Beta-catenin and it is anticipated that within one year following the completion of the merger we would able enter clinical testing against colorectal cancer.
A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.
Beta-catenin is subsequently translocated into the nucleus to form a transcriptionally active [beta]-catenin T-cell factor/lymphoid enhancer factor deoxyribonucleic acid-binding complex that regulates the Wnt target gene.
The new study shows that at certain genes OCT4 also collaborates with transcription factors that are activated by external signals, such as the retinoic acid (vitamin A) receptor (RAR) and beta-catenin, to turn on their respective genes.
It has recently been reported that it is also involved in the Wnt pathway and serves by binding to and promoting beta-catenin translocation into the nucleus [9].
5 In our case also, modalities like MRI and ultrasound-guided fine-needle aspiration cytology (FNAC) failed to give any picture of problem and conclusive diagnosis was based on histopathology of excised lesion, and positive expression of beta-catenin.