Effects of different concentrations of glucose on proliferation, secretory function and apoptosis in mouse pancreatic beta-cell
line NIT-1 (Chinese).
Thanks to previous research, they knew that when the insulin pathway is blocked in the liver, there's some process that induces the pancreas to make more insulin-secreting beta-cells
The rote of incretins in beta-cell
regeneration is now being recognised.
After completion of three years of therapy, a four-week off-drug period followed to allow assessment of parameters of metabolic state including beta-cell
1] In patients with type 2 diabetes, beta-cell
death is increased and the number of beta-cells
As part of this collaboration, NGM will apply its integrated discovery technology and in vivo screening platform to identify and validate physiologically-relevant metabolic targets that modulate beta-cell
growth and function.
In 2 to 5 percent of patients with a form of type 2 diabetes known as maturity onset diabetes of the young (MODY), defects involving genes essential for beta-cell
function have been found.
5,6) Furthermore, in animal models, liraglutide has been shown to decrease beta-cell
apoptosis (programmed cell death) and increase beta-cell
Rather than studying children diagnosed with diabetes, they tested 253 asymptomatic children for beta-cell
autoimmunity, an early predictor of the disease.
Chief of Endocrinology and Metabolism at the University of Virginia whose group presented the results at the ADA's Session on Beta-Cell
Data on beta-cell
compensation to insulin resistance is also provided by this test, and differences were detected between strains of animals.
In healthy people, the beta cells' tight regulation of insulin and amylin might prevent blood sugar from soaring too high or dipping too low, whereas some beta-cell
abnormality could lead to an amylin excess, he theorizes.