Role of apoptosis in pancreatic beta-cell
death in diabetes.
The trial, carried out by Health Diagnostic Laboratory Inc (HDL), tested 1,687 patients at risk for cardiovascular disease under routine clinical care with a comprehensive panel of biomarkers associated with IR, beta-cell
function and glycemic control.
Effects of different concentrations of glucose on proliferation, secretory function and apoptosis in mouse pancreatic beta-cell
line NIT-1 (Chinese).
Adult pancreatic beta-cells
are formed by self-duplication rather than stem-cell differentiation.
Thanks to previous research, they knew that when the insulin pathway is blocked in the liver, there's some process that induces the pancreas to make more insulin-secreting beta-cells
Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell
mass in diabetes: significance, mechanisms and therapeutic implications.
But in the others, the cells switched on a critical beta-cell
gene, churned out insulin in response to glucose, and cured the animals.
Through techniques of gene therapy and genetic engineering, the researchers have also been able to repair the defects in the PHHI cells, and now they hope to translate their discovery into the production of "super beta cells"-infinitely reproducible beta-cell
lines that could be implanted into humans and have the potential to be resistant to autoimmune destruction.
Attempts so far to preserve beta-cell
function have centered on still-experimental efforts to suppress the body's immune system.
The patent application, entitled Pharmaceutical compositions and methods for restoring beta-cell
mass and function, also covers the use of LSF in combination with a growth factor.
the paper's senior author and director of the Vanderbilt Diabetes Center, said that the study "provides clues to how we might learn what signals promote beta-cell
regeneration in type 1 and type 2 diabetes.