beta cell

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beta cell

[′bād·ə ‚sel]
(histology)
Any of the basophilic chromophiles in the anterior lobe of the adenohypophysis.
One of the cells of the islets of Langerhans which produce insulin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Accili, "Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1," The Journal of Biological Chemistry, vol.
Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: Downregulation of glucokinase in pancreatic beta-cells.
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008; 455: 627-632, doi: 10.1038/nature07314.
Additionally, GLP-1 is also known to expand beta-cell mass by stimulating [beta]-cell proliferation and inhibiting [beta]-cell apoptosis [7-10].
There are still some questions to be answered 6 primarily, figuring out how betatrophin acts on pancreatic beta-cells. But the finding definitely opens the door to a possible therapy for type 2 diabetes, and possibly lead to treatments for type 1 diabetes, also called childhood diabetes.
Activation of Akt signaling in transgenic mice constitutively overexpressing activated Akt in beta-cells resulted in increased islet mass, largely due to neogenesis and proliferation of beta-cells, and improved glucose tolerance [66, 67].
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Through techniques of gene therapy and genetic engineering, the researchers have also been able to repair the defects in the PHHI cells, and now they hope to translate their discovery into the production of "super beta cells"-infinitely reproducible beta-cell lines that could be implanted into humans and have the potential to be resistant to autoimmune destruction.
In nondiabetics, pancreatic beta-cells produce insulin, the hormone that allows sugar to be burned as energy.
Mansouri, "Pancreatic beta-cells: from generation to regeneration," Seminars in Cell and Developmental Biology, vol.