A major clinical focus during the diagnosis of DIHS and the selection of the most appropriate treatment is whether the reactivation of members of the
Betaherpesvirinae subfamily, including HHV-6, develops subsequently to the drug hypersensitivity reaction [1-4].
In a BLASTx search, 1 cDNA fragment (deduced sequence of 29 aa) was homologous to the glycoprotein B (gB) amino acid sequence of the tupaiid herpesvirus 1 (TuHV-1) (79% identity), which belongs to subfamily
Betaherpesvirinae. We designed new consensus-degenerate hybrid oligonucleotide primers (http://blocks.fhcrc.org/codehop.html) selective for the betaherpesvirus gB and DNA polymerase (DPOL) genes, and we determined the complete gB sequence and the partial DPOL sequence of the isolated virus (5,029 bp, DNA Data Bank of Japan accession no.
La familia esta conformada por tres subfamilias: Alphaherpesvirinae,
Betaherpesvirinae y Gammaherpesvirinae.
Furthermore we have evaluated the inhibitory activity of this particular Phyllanthus species against HCMV, a member of
Betaherpesvirinae subfamily.
The herpesviruses are divided into three subfamilies: Alphaherpesvirinae (herpes simplex virus),
Betaherpesvirinae (cytomegalovirus), and Gammaherpesvirinae (Epstein-Barr virus).
