Beutler, Bruce Alan

Beutler, Bruce Alan,

1957–, American immunologist and geneticist, b. Chicago, Ill., M.D. Univ. of Chicago, 1981. Beutler has been a professor and physician at Rockefeller Univ. (1984–86), a faculty member at the Univ. of Texas Southwestern (1986–2000, 2011–), and a professor at Scripps Research Institute, La Jolla, Calif. (2000–2011). In 2011 he and Jules HoffmannHoffmann, Jules Alphonse,
1941–, French biologist, Ph.D. Univ. of Strasbourg, 1969. Hoffmann was a researcher at the French National Center for Scientific Research, Strasbourg, from 1974 to 2009.
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 were awarded the Nobel Prize for Physiology or Medicine for their discoveries concerning the activation of innate immunity; they shared the prized with Ralph SteinmanSteinman, Ralph Marvin,
1943–2011, Canadian biologist, M.D. Harvard Medical School, 1968. He was a researcher and professor at Rockefeller Univ., New York City, from 1970 until his death in 2011.
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, who was recognized for his discovery of dendritic cells. Beutler isolated a type of protein produced by dendritic cells called tumor necrosis factor, which plays a role in the body's response to inflammation. He also discovered proteins called Toll-like receptors, which are used by the immune system to recognize viruses and trigger the body's response to infection.
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