All recording slices were treated with phaclofen or bicuculine with asiatic acid various concentrations, while the other drug-untreated control was treated with phaclofen or bicuculine containing no asiatic acid.
The blocking effects are considerably greater in slices with concentration of 100 [micro]M with GABAA antagonist, bicuculine. In contrast, asiatic acid, even at the high concentration of 100 [micro]M, exerted no effect with GABAB antagonist, phaclofen.
Dihydropyridine calcium channels blockers in experimental seizures by ischemia, bicuculine
, electrical cortical shocks, nitrous oxide and alcohol withdrawal syndrome is caused due, have anticonvulsant effects .