The rate limiting step in
bile salt excretion is transport at the canalicular membrane, as there is a high concentration gradient to overcome in order to excrete
bile salts into the bile acid pool.
Human drug-induced liver injury severity is highly associated to dual inhibition of liver mitochondrial function and
bile salt export pump.
The researchers sequenced stool microbial components and conducted
bile salt metabolomic profiling.
The
bile salts concentration was 2.4 mM in the aspirates used in the present study, whereas, the aspirates used by Devle et al.
The investigators found similar plate counts between ALG and POPL microcapsules when they were exposed to
bile salts. This suggests that an extra coating of POPL could be readily broken down by
bile salts commonly found in the lower gastrointestinal tract.
In the study, the children with cancer had inherited a faulty gene from both parents which stopped a protein, called
bile salt export pump (BSEP), being produced.
Therefore, in this investigation, we studied the effect of [alpha]-asarone on the activity of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate-limiting enzyme in cholesterol biosynthesis, and on the balance between circulating lipoproteins-cholesterol level and bile secretion, as well as on the levels of cholesterol, phospholipids and
bile salts secreted in bile, in order to find evidences to support a possible mechanism of action of [alpha]-asarone related to its hypocholesterolemic and cholelitholytic effects in hypercholesterolemic rats.
It appeared that for fasting conditions, approximately 25% of the PCBs were sorbed to
bile salt micelles, 15% to digestive proteins, and 60% were still sorbed to the soil.
Bile salts, and in particular cholic acid, which is of interest to the pharmaceutical industry, have already been identified as a potential target: Positive preliminary recycling results using a first generation cholic acid polymer have been obtained.
About 16 enzymes are needed to convert cholesterol to
bile salts. Hepatocytes also conjugate
bile salts with glycine or taurine.
However, certain components in these media such as
bile salts and phospholipids raised suspicions regarding the possible toxic effects on cell lines (Ingels and Augustijns 2003; Birch et al.
Swarming of P mirabilis can also be inhibited on media like Deoxycholate citrate agar (DCA) and MacConkey agar which contains
bile salts. In the present study imipenem, cefixime and amikacin used to prevent the swarming of P.
