Within the cervical mass, all monomorphic and blastoid
cells (presumed neoplastic lymphoid cells) and few individual, nonneoplastic cells within mixed aggregates showed strong positive cytoplasmic immunoreactivity for CD3 (Fig 3B).
Loghavi et al., 2015 , have reported five cases of Tdt-positive B-cell neoplasms with BCL2 rearrangements and MYC rearrangements; four of these had high-grade blastoid
neoplasms at presentation while the fifth case was transformed from preceding follicular lymphoma.
In this study one case was diagnosed as blastoid
mantle cell lymphoma as it was reactive for CD20, CD5 and negative for CD23.
types MCL are more aggressive than MCL and associated with a worse clinical outcome.
(** Denotes holotype, * specimen crushed.) TABLE 1 Blastoid
and Crinoid fauna of the Columbus Limestone.
Ontogeny and phylogeny of the Carboniferous blastoid
He concludes that if the ancient echinoderms had similar characteristics, snails would have been better off to treat blastoid
and crinoids as long-term hosts rather than as prey.
Likewise, frequency of pleomorphic or blastoid
morphology (8% at diagnosis; 31% at relapse) was not significantly different compared with the larger unselected series of MCL.
The pathology specimen was reviewed and showed lymphomatous involvement with sheets of medium-sized cells with blastoid
morphology characterized by fine chromatin, occasional distinct nucleoli, and scant cytoplasm.
Although leukemic phase of blastoid
MCL can be a difficult differential diagnosis of B-PLL, in the index case, the monomorphic population of atypical lymphocytes with characteristic morphology and immunophenotyping characteristics tilted our diagnosis in favor of B-PLL short of cyclin D1 staining and cytogenetics.
After extensive phylogenetic study involving careful character analysis, he found that the Permian survivors among blastoid
echinoderms were drawn from many branches of the evolutionary tree.
Severe anemia and blastoid
cells were observed in the peripheral blood.