The team is currently working to improve the particles' cancer-fighting abilities by increasing their potential to block blood vessels
and by designing hollow nanoparticles that can also deliver chemotherapy drugs.
Obviously, a better understanding of what is different in blood vessels
at the tumor site is essential to tailor drugs more specifically to focus on the site of disease.
"Other groups are investigating the use of specialized radiation treatments to selectively destroy new blood vessel
development," says Dr.
Some patients have the ability to grow new blood vessels
naturally but others lack either the protein or the receptor to stimulate organic growth.
Martin Friedlander, PhD and colleagues at the Scripps Research Institute in LaJolla, CA studied endothelial precursor cells (EPCs), a subset of hematopoietic stem cells that forms blood vessels
. According to their report in an advance online publication of the September issue of Nature Medicine, hematopoietic stem cells that contain large quantities of EPCs can be used to both promote and inhibit the growth of blood vessels
in the retina.
For example, when we're infants we grow new blood vessels
. When we're adults we do so, but in only a very limited way.
In a process known as atherosclerosis, fatty substances build up inside the walls of blood vessels
. Blood components also stick on the surface inside vessel walls.
This barrier is a "wall" of tiny endothelial cells in the blood vessels
that permeate the brain tissue, nourishing it and providing oxygen.
Even with careful insulin treatment, people who have had diabetes for years are at greater than average risk of developing problems that involve the heart, blood vessels
, eyes, kidneys, and nerves.
[USA], November 23 (ANI) - Researchers have identified a signaling pathway that is essential for the growth of new blood vessels
from pre-existing blood vessels
IRVINE, Calif., May 16, 2017-By using induced pluripotent stem cells (iPSCs) to create endothelial cells that line blood vessels
in the brain for the first time for a neurodegenerative disease, scientists here have learned why Huntington's disease patients have defects in the blood-brain barrier that contribute to the symptoms of this fatal disorder.