Bohr effect


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Bohr effect

[′bȯr i′fekt]
(biochemistry)
The effect of carbon dioxide and pH on the oxygen equilibrium of hemoglobin; increase in carbon dioxide prevents an increase in the release of oxygen from oxyhemoglobin.
References in periodicals archive ?
Similar observations have come from genetically engineered Hbs: the exchange of [Lys.sup.66] by site-directed mutagenesis to Ser-66, Arg-66, or Thr-66 led to 1.3-, 1.5-, and 2.3-fold reductions in oxygen affinity, respectively, but allosteric properties such as the Bohr effect and the effect of inositol hexaphosphate were well preserved (10).
At variance with human hemoglobin, the alkaline Bohr effect for [beta](V1M+H2[DELTA]) is not sensitive to the presence of [Cl.sup.-].
They found an increased oxygen affinity with a normal Bohr effect. The DPG and inositol hexaphosphate effects were normal, but the sensitivity to chloride had increased by 30%.