Suppression

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suppression

[sə′presh·ən]
(computer science)
Removal or deletion usually of insignificant digits in a number, especially zero suppression.
Optional function in either on-line or off-line printing devices that permits them to ignore certain characters or groups of characters which may be transmitted through them.
(electronics)
Elimination of any component of an emission, as a particular frequency or group of frequencies in an audio-frequency of a radio-frequency signal.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Suppression

 

in genetics, a phenomenon that prevents the appearance of a character resulting from mutation and that causes partial or complete restoration of the normal phenotype.

Intragenic suppression is caused by a second (suppressor) mutation in the same gene in which the first (direct) mutation occurred. Intergenic suppression is caused by a second mutation in other genes that are located at a considerable distance from the suppressed gene. In intragenic suppression, a protein coded by a given gene can reacquire functional activity, although its original structure, in contrast to true reverse mutation, or reversion, is not restored. In intergenic suppression, the normal phenotype may be restored in some cases owing to mutations that permit other means of metabolism which do not require the functioning of the given gene. In other cases, the normal phenotype may be restored as a result of mutations that alter the process by which the genetic information of the mutant gene is realized.

The phenomenon of suppression, first discovered in 1920 by the American geneticist A. H. Sturtevant, is used to study the genetic code and other aspects of molecular genetics.

REFERENCE

Stent, G. Molekuliarnaia genetika. Moscow, 1974. Chapter 6. (Translated from English.)

I. I. TOLSTORUKOV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The patient's bone marrow was not hypocellular; therefore, diagnosis of bone marrow suppression secondary to drug use was also eliminated.
There was no evidence of bone marrow suppression as WBCs, RBCs, and reticulocytes were all within the normal limit.
Since the patient improved very well on ART at the end of 10 months, the most likely cause of bone marrow suppression in this patient is direct HIV infection of marrow progenitor cells.
In addition, the number of PCEs among 1000 NCEs per animal was recorded to evaluate bone marrow suppression; mitotic activity was calculated as % PCE = [PCE/(PCE + NCE)] x 100 as a direct index of cell division.
Although, repeated peripheral smears for malarial parasites were negative, bone marrow biopsy did help uncover the culprit falciparum causing acute bone marrow suppression and skin rash.
Clopidogrel may be found to be associated with severe bone marrow suppression manifested as bone marrow failure (2), aplastic anemia, thrombocytopenia, neutropenia.
Most causes of death that are associated with methotrexate are attributable to bone marrow suppression, not hepatotoxicity.
It's not commonly recognized that most causes of death that are associated with methotrexate are attributable to bone marrow suppression, not hepatotoxicity.
Severe thrombocytopenia also limits one's treatment options, as many drugs cause bone marrow suppression and peripheral platelet consumption.
A complete blood count was obtained at 3 weeks, to coincide with the expected nadir for bone marrow suppression (Polovich, White, & Kelleher, 2005).
For example, higher cytotoxic plasma levels would lead to increased bone marrow suppression, increased febrile neutropenia, and a predisposition to AML / MDS, with increased predisposition also to use of granulocyte colony-stimulating factor," he explained.

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