Indeed, the new guidelines rate the quality of data supporting PDT as first-line therapy for actinic keratoses, Bowen disease, and superficial BCCs as level IA--the highest-possible grade of evidence, requiring at least one well-designed, randomized, controlled trial, he noted at a satellite symposium held in conjunction with the 11th World Congress on Cancers of the Skin, cosponsored by the Skin Cancer Foundation and Erasmus University.
He said that he personally finds PDT particularly useful for treatment of large, superficial BCCs and Bowen disease.
2 Pagetoid dyskeratosis - - - - + - Extramammary Paget disease + + + - + + Epidermotropic carcinoma + + + - + + Pagetoid Bowen disease
- - - - + - Pagetoid melanoma - - - + - - 34[Beta]E12 CEA HPV HMB-45 Pagetoid dyskeratosis + - - - Extramammary Paget disease - + - - Epidermotropic carcinoma - + - - Pagetoid Bowen disease
+ - ND - Pagetoid melanoma - - - + (*) PAS indicates periodic-acid Schiff; AB, Alcian blue at pH 2.