The intensity varied with the distribution of the lesion with very slight immunostaining in the pneumocytes, interstitial macrophages, and in blood vessels; while the bronchial, bronchiolar epithelium
and the luminal exudates with macrophages in the bronchial associated lymphoid tissue stained strongly.
It is a rare condition characterized by generalized proliferation of neuroendocrine cells confined to bronchial and bronchiolar epithelium
.  The disease causes chronic respiratory symptoms which usually misdiagnosed as asthma or chronic obstructive pulmonary disease.
Peribronchiolar metaplasia (PBM, known in the past as lambertosis) refers to very fine, interstitial fibrosis that radiates outward from a bronchiole, with the fibrotic alveolar walls covered by metaplastic, ciliated bronchiolar epithelium
Toxicokinetics affecting concentrations at the bronchiolar epithelium
substantially drive the risk of bronchiolitis obliterans from irritant gases.
Chinet, "Ion and liquid transport across the bronchiolar epithelium
," Respiratory Physiology & Neurobiology, vol.
The lymphocytes infiltrated bronchiolar epithelium
forming well-defined lymphoepithelial lesions.
Histological changes in the lung revealed degenerative changes in the bronchiolar epithelium
while damaged endothelial cells were observed.
Moreover, exocrine bronchiolar cells secret surfactant like material keep the patency of the bronchiole and exocrine bronchiolar cell also regenerate the bronchiolar epithelium
(Fraser; Fawcett, 1994) in humans, this study recorded that the Neuroendocrine cells constitute about 4 to 5% of bronchial epithelial cells and.
(2) Early in the disease course, the offending cells are abundant in proximal bronchial and bronchiolar epithelium
. (1,2) This pattern of distribution is consistent with histologic and radiologically evident features of the condition.
Viral antigen was detected in neurons in the brain, bronchiolar epithelium
and macrophages in the lungs, bile duct epithelium in the liver, and macrophages and lymphocytes in lymph nodes.
Stem cells found along the surfaces of the airways (in the bronchiolar epithelium
) proliferate rapidly in mice after viral infection and migrate to sites of damage.
The inflammatory response to viral replication in the bronchiolar epithelium
is characterized by necrosis and sloughing of the small airways epithelium, with edema and increased secretion of mucus by goblet cells, which occludes the flow of terminal airways.