Histological changes in the lung revealed degenerative changes in the bronchiolar epithelium
while damaged endothelial cells were observed.
Thus, the bronchiolar epithelium
will demonstrate only partial invaginations around the intraluminal material.
2) Early in the disease course, the offending cells are abundant in proximal bronchial and bronchiolar epithelium
Viral antigen was detected in neurons in the brain, bronchiolar epithelium
and macrophages in the lungs, bile duct epithelium in the liver, and macrophages and lymphocytes in lymph nodes.
The inflammatory response to viral replication in the bronchiolar epithelium
is characterized by necrosis and sloughing of the small airways epithelium, with edema and increased secretion of mucus by goblet cells, which occludes the flow of terminal airways.
Use of micro-dissected airways to better define metabolism and cytotoxicity in murine bronchiolar epithelium
We move silently and cleanly about our towns or countryside at almost no risk to anyone else, and (this puts us even more on the side of the angels) we leave the air cleaner than we find it, thanks to the trapping of airborne particulate debris by the mucous sheet covering our bronchial and bronchiolar epithelium
When the alveolated structures are lost, a distorted ectatic terminal bronchiole, lined by bronchiolar epithelium
, is left, which is why the changes of UIP are dominantly subpleural or periseptal, because this is where distal lung acini terminate.
The immunohistochemical study demonstrated morbilliviral antigen in bronchiolar epithelium
, type 2 pneumocytes, and multinucleate (syncytial) cells from lung (Figure 1).
The infiltration of inflammatory cells into the lung is responsible for further damage to tracheal and bronchiolar epithelium
All patients had open lung biopsies and were studied in detail according to architecture, temporal homogeneity, distribution of lesions, damage to bronchiolar epithelium
, fibroblastic foci, and air space remodeling.
Attachment to bronchiolar epithelium
was moderate in seals and scarce in cetaceans, and attachment to alveolar epithelium was scarce in all 4 species.