Brown, Michael Stuart

Brown, Michael Stuart,

1941–, American molecular geneticist, b. New York City, M.D. Univ. of Pennsylvania, 1966. He worked (1968–71) as a researcher at the National Institutes of Health before going to the Southwestern Medical School of the Univ. of Texas at Dallas. Brown and colleague Joseph L. GoldsteinGoldstein, Joseph Leonard
, 1940–, American molecular geneticist, b. Sumter, S.C., M.D. Univ. of Texas at Dallas, 1966. He worked as a biomedical researcher at the National Heart Institute (1968–70) and Washington Univ.
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 researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is a major cause of cholesterol-related diseases. In 1985, Goldstein and Brown were jointly awarded the Nobel Prize in Physiology or Medicine.
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