Bruch's membrane

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Related to Bruch's membrane: Drusen, choriocapillaris, Retinal pigment epithelium

Bruch's membrane

[′brüks ‚mem‚brān]

(anatomy)

The membrane of the retina that separates the pigmented layer of the retina from the choroid coat of the eye.

References in periodicals archive ?

The highly effective responses obtained with anti-VEGF injections were attributed to enhanced passage of the bevacizumab through the thinned and degenerated RPE and Bruch's membrane to the subretinal area, thus increasing the drug's efficacy.

Choroidal osteoma and secondary choroidal neovascularization treated with ranibizumab

The intracellular lipid accumulation in RPE leads to AMD that appears in the form of Bruch's membrane deposits and drusen.

Serum APOE, leptin, CFH and HTRA1 levels in Pakistani age related macular degeneration patients

10 Similar changes occur in elastic fibres of the blood vessels, Bruch's membrane of the eye, endocardium and other organs.

Familial pseudoxanthoma elasticum: Report of three case series in a single family

choriocapillaris, Bruch's membrane, RPE, and photoreceptors), and changes in each of these structures may contribute to varying degrees to the onset of AMD (Figure 2).

Relationship between Oxidative Stress, Circadian Rhythms, and AMD

The presumed pathogenesis is pressure deformity of the border of Bruch's membrane at the level of the optic nerve head creating a discontinuity of the normal anatomic apposition of the chorioretinal layers.

Intravitreal bevacizumab for peripapillary subretinal neovascular membrane associated to papilledema: a case report

2) They result from a rupture of the elastic tissue in the Bruch's membrane of the retina.

A curious case study: our patient had developed skin folds on her neck, and her vision was deteriorating. Interestingly, her sister had the same complaints

Using aged submacular human Bruch's membrane explants in organ culture, we reproduced the incomplete and aberrant RPE resurfacing seen in AMD patients following CNV excision [24].

Migration and proliferation of retinal pigment epithelium on extracellular matrix ligands

A breakdown in the Bruch's membrane usually occurs near drusen deposits, and this is where the new blood vessel growth occurs (neovascularization).

Breakthroughs in treating macular degeneration: once considered untreatable, age-related macular degeneration (AMD) is yielding exciting "insights" into methods of prevention and promising new treatments

Statins may prevent the accumulation of basal linear deposit in Bruch's membrane, which occurs in patients with high cholesterol levels.

Statins, Macular Degeneration

Statins may prevent accumulation of basal linear deposit in Bruch's membrane, which occurs when cholesterol levels are high.

Statins, macular degeneration. (Clinical Rounds)

It has been postulated that in old age, this material is released from the RPE and renders the overlying Bruch's membrane hydrophobic.

Loss of vision in the ageing eye

The TIMP3 mutations may promote excessive growth of blood vessels through Bruch's membrane, which lies below the retina, they speculate.