Brunner's glands

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Related to Brunner glands: Duodenal glands

Brunner's glands

[′brən·ərz ‚glanz]
(anatomy)
Simple, branched, tubular mucus-secreting glands in the submucosa of the duodenum in mammals. Also known as duodenal glands; glands of Brunner.
References in periodicals archive ?
The key histologic criteria include (1) dilated ducts and pseudocystic changes in the duodenal wall, (2) duodenal submucosal fibrosis extending to the adjacent soft tissue in the groove area and pancreas, and (3) variable Brunner gland hyperplasia forming a thick layer with surrounding smooth muscle and myofibroblastic proliferation.
Characteristics of Groove Pancreatitis Patient population Men > women 40-50 y Alcohol consumption Clinical presentation Severe abdominal pain, mostly epigastric Obstructive symptoms: nausea, vomiting, weight loss Jaundice: rare Imaging: computed tomography Thickened duodenal wall with luminal stenosis Hypodense mass between pancreas and duodenum Cysts Pancreatic duct may be uninvolved Cytology Spindled epithelioid cells with oval nuclei, small nucleoli Background granular/necrotic debris Bland epithelial cells with foamy cytoplasm Histology Fibrosis/scarring Myofibroblastic proliferation Brunner gland hyperplasia Treatment of choice Pancreaticoduodenectomy
Brunner gland hyperplasia first described by swiss physician Johann Conrad brunner.
According to the most prevalent finding, paraduodenal pancreatitis has been reported as Brunner gland hamartoma, as leiomyoma or sarcoma, or as duodenal duplication.
There were also hyperplastic lobules of Brunner gland, lined by cylindrical clear mucinous cells with basal hyperchromatic nuclei (Figures 1 and 2).